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P50 - Small Cell Lung Cancer/NET - Real World Outcomes (ID 232)
- Event: WCLC 2020
- Type: Posters
- Track: Small Cell Lung Cancer/NET
- Presentations: 1
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
P50.05 - Clinical Features and Outcome of Small Cell Lung Cancer in Female Patients: From SEER Database and a Cohort. (ID 2477)
00:00 - 00:00 | Presenting Author(s): Jia Hou
Currently, female small cell lung cancer (SCLC) incidence has been increasing. However, there have been few large database-based studies on female patients with SCLC. In this study, we used Surveillance, Epidemiology, and End Results (SEER) database to describe the clinical characteristics and prognosis of female SCLC patients, and one cohort from a single institution in China was enrolled for validation.
SCLC patients from the SEER database between 1973 and 2015 were included. Patients with SCLC were extracted from the First Affiliated Hospital of Xi'an Jiaotong University between 2014 and 2017, and following-up was obtained till March 2019. Clinical characteristics were analyzed among females and males with SCLC. Survival analyses were conducted with log-rank tests and Cox proportional hazard models.Results
A total of 18234 patients were extracted from SEER database and 342 patients were collected from the First Affiliated Hospital of Xi'an Jiaotong University. 50.2% and 21.3% of the whole SCLC patients were females in SEER database and in our single institution cohort, retrospectively. Gender proved to be an independent prognostic factor for SCLC patients (HR, 1.120; 95% CI: 1.084-1.158; P < 0.001) . Female patients presented longer overall survival (OS) than male patients (SEER: Median OS:11 vs. 9 months, P<0.001; Single institution cohort: Median OS: 16 vs. 12months, P<0.05) (Figure 1). Compared with males, females were less likely to be Asians, carry bigger size of tumor, have later TNM stage, and have distant metastases (P<0.05). Our results confirmed that age≥65, white race, later stage, tumor size≥50mm and distant metastases were all associated with poor OS in female patients (Figure 2).
Female gender is associated with more favorable outcome of SCLC. For females, patients who are senile, white people, and have poorer pathological features were associated with a shorter OS, which need to be more circumspectly treated in clinical practice.
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