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Masao Saito
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P22 - Mesothelioma, Thymoma and Other Thoracic Malignancies - Case Reports (ID 136)
- Event: WCLC 2020
- Type: Posters
- Track: Mesothelioma, Thymoma and Other Thoracic Malignancies
- Presentations: 2
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P22.04 - Lung Metastasis of Thyroid Transcription Factor 1 Positive Endometrioid Carcinoma; A Case Report (ID 1756)
00:00 - 00:00 | Presenting Author(s): Masao Saito
- Abstract
Introduction
Thyroid transcription factor 1 (TTF-1) is a protein which regulates transcription of genes specific for thyroid, lung, and diencephalon, and is used in anatomic pathology as a marker to determine if a tumor arises from lung or thyroid. TTF-1 positive rate in endometrial carcinoma (Grade 1-2) is as rare as 2%. We present a solitary pulmonary metastasis case from TTF-1 positive endometrioid carcinoma.
Methods
A 84-year-old woman was addressed to our institution for an abnormal shadow in the chest. Chest CT showed 14mm nodule in the right lower lobe. She had a previous history of surgically resected endometrioid carcinoma (Grade 2) of the uterine corpus.
Results
Video assisted thoracic surgery was performed for diagnostic and therapeutic purposes. Intra-operative diagnosis was suspected lung metastasis of endometrioid carcinoma. Immunohistochemical staining revealed positive estrogen receptor, TTF-1 and PAX8. Based on the results, we made a diagnosis of metastatic endometrioid carcinoma. The postoperative course was uneventful.
Conclusion
TTF-1 positive endometrioid carcinoma is rare. Medical history and immunohistochemistry are useful for differentiating from primary lung cancer. TTF-1 positive endometrioid carcinomas have reported a poor prognosis and require careful follow-up.
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P22.08 - Paraganglioma of the Anterior Mediastinum. (ID 3351)
00:00 - 00:00 | Author(s): Masao Saito
- Abstract
Introduction
Pheochromocytoma and paraganglioma are catecholamine-producing tumors that arise from the adrenal glands or paraganglia. These tumors rarely occur in the chest, especially the anterior mediastinum. Here, we describe a rare case of paraganglioma of the anterior mediastinum, and report on the key points of surgery and perioperative management.
Methods
An 80-year-old woman was admitted to our hospital for fatigue and hypertension. A 123I-meta-iodobenzylguanidine scintigraphic scan revealed an anterior mediastinal tumor with a high signal intensity. Chest computed tomography showed a 44-mm mass in the anterior mediastinum adjacent to the ascending aorta and superior vena cava. The mass showed low signal intensity in T1-weighted images and high signal intensity in T2-weighted images. A pheochromocytoma of the right adrenal gland had been removed from the patient 35 years earlier.
Results
The present mediastinal tumor was removed using video-assisted thoracic surgery after controlling the patient’s blood pressure. There were three drainage veins, and unlike the adrenal gland, it was relatively difficult to identify the inflow and outflow vessels. Nevertheless, the surgery was successful and the postoperative course was uneventful.
Conclusion
When performing surgery for paraganglioma of the anterior mediastinum, attention must be paid to the presence of inflow and outflow vessels. In addition, good blood pressure control prior to surgery is needed to reduce the risk of complications during the perioperative period.
