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EP1.01 - Advanced NSCLC (ID 150)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Advanced NSCLC
- Presentations: 1
- Now Available
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
EP1.01-89 - Retroperitoneal Metastasis with Marked Fibrosis from Lung Adenocarcinoma: An Autopsy Case Report (Now Available) (ID 606)
08:00 - 18:00 | Author(s): Atsuhiko Sakamoto
Retroperitoneal metastasis of lung cancer is rare. Here we report a unique case of retroperitoneal metastasis with fibrosis from lung adenocarcinoma. Case: A 73-year-old woman was admitted to the hospital in June 2018 because of nausea and vomiting of a few days' duration. In February 2018 she had received a diagnosis of lung adenocarcinoma (clinical T3N3M1a stage IVA, epidermal growth factor receptor [EGFR] mutation positive, exon 19 deletion) in the right lower lung and was taking afatinib 20 mg once daily. On admission, chest radiography and computed tomography (CT) showed that the primary tumor was smaller than at the time of diagnosis; however, abdominal CT showed a new retroperitoneal lesion and right hydronephrosis. Contrast-enhanced CT and MRI scan revealed poorly marginated soft tissue around the duodenum and inferior vena cava. She underwent gastrojejunostomy and biopsy of the peritoneum after duodenal obstruction was revealed by examination of the upper gastrointestinal tract (Figure 1). Analysis of the biopsy specimen revealed EGFR mutation–positive adenocarcinoma with exon 19 deletion, which was consistent with retroperitoneal metastasis of the lung adenocarcinoma. She was treated with CBDCA/PEM and CBDCA/PEM/BV each one cool [DK1] but developed cerebral infarction and died 104 days after admission.
Section not applicableResult
Autopsy showed that right ureteral obstruction and hydronephrosis were caused by markedly sclerotic retroperitoneum. Histopathologic examination revealed marked fibrosis with scattered adenocarcinoma (Figure 2).
Although rare, metastasis of non–small lung cancer should be considered in patients with doudenal obstruction or hydronephrosis.
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