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Choon-Taek Lee

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    P2.03 - Biology (ID 162)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Biology
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.03-30 - Genetic Characteristics of Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis (ID 369)

      10:15 - 18:15  |  Author(s): Choon-Taek Lee

      • Abstract


      Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, the genetic alteration contributing to lung cancer development from IPF has not been elucidated. The objective of this study is to investigate the genetic characteristics of IPF-related lung cancer by using next-generation sequencing.


      Patients with IPF who diagnosed lung cancer and underwent pulmonary resection surgery at Seoul National University Bundang Hospital were included. We extracted DNA from three parts of pathologic specimen of the same patient; normal, IPF, and lung cancer tissue. Using the DNA extracted from each tissue, whole exome sequencing was performed.


      Twenty consecutive IPF patients with lung cancer were included. Median age at diagnosis was 72 years, all patients were male and 19 patients (95%) were former or current smokers. Fourteen patients (70%) had squamous cell carcinoma, five patients (25%) had adenocarcinoma, and one (5%) had large cell carcinoma. TP53 (10/20, 50%) was the most frequently identified genetic mutation in lung cancer tissue, followed by LILRB4 (9/20, 45%). These genetic mutations were not observed in IPF tissue of the same patient. The genetic mutations of FAM231B (5/20, 25%), PSPN (4/20, 20%), GNAQ (4/20, 20%) were also observed in lung cancer tissue, but not in IPF tissue. Genetic mutations of PRH2 and THAP12 were identified both IPF and lung cancer tissue. The frequency of mutations was observed to increase in the order of normal, IPF, and lung cancer tissue (PRH2, 12% vs 35% vs 40%; THAP12, 6% vs 20% vs 25%).

      fig 1_iaslc.png


      Various genetic mutations are associated with the development of lung cancer from IPF. Certain sequential patterns of genetic mutations may be present in IPF-associated lung cancer. Our findings provide insight into the genomic landscape about IPF-related lung cancer.

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    S01 - IASLC CT Screening Symposium: Forefront Advances in Lung Cancer Screening (Ticketed Session) (ID 96)

    • Event: WCLC 2019
    • Type: Symposium
    • Track: Screening and Early Detection
    • Presentations: 1
    • Now Available
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      S01.05 - Panel Discussion (Now Available) (ID 3631)

      07:00 - 12:00  |  Presenting Author(s): Choon-Taek Lee

      • Abstract
      • Presentation
      • Slides

      Abstract not provided

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