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Zhen-Yu Ding

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      127P - Obesity has an impact on the efficacy of EGFR-TKI in NSCLC patients harbouring EGFR mutation: A real-world study (ID 485)

      12:30 - 13:00  |  Presenting Author(s): Zhen-Yu Ding

      • Abstract


      EGFR-TKI has become the standard-of-care therapy for advanced NSCLC harbouring EGFR mutation. However, the efficacy varies widely, suggestive of other confounding factors. Obesity is related to the etiology, morbidity, and mortality of cancer. However, its impact on the efficacy of EGFR-TKI remains unknown.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      This was a multi-center, real-world study conducted in 3 tertiary referring medical centers. Treatment-naive metastatic NSCLC patients harbouring EGFR mutation who were prescribed with TKI (gefitinib, erlotinib, or icotinib) were enrolled. Body Mass Index (BMI) was proposed as the indicator of obesity. The PFS of all patients were collected and analyzed.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      The training cohort (n = 321) consisted consecutive patients in West China Hospital from Sept 2010 to Jul 2018. The total PFS was 12.1m (95%CI: 11.2-13.0m). Those with a high BMI (>22.8) achieved a longer PFS than their counterparts (10.9 and 13.8 m, HR 0.68, 95% CI: 0.54-0.86, P = 0.001). Although the cut-off value was set-up by ROC analysis, the superiority was irrespective of the artificially-defined cut-off value (median 22.9, quadrant value 22.5 or 25). Additionally, the difference was confirmed in an independent validation cohort (n = 108) in 3 tertiary referring medical centers. The PFS was 11.3 and 13.7 m (HR 0.74, 95% CI: 0.61-0.91, P = 0.004). Interestingly, the influence of obesity was restricted in men (HR 0.45, 95% CI: 0.31-0.65, P<0.0001), while not in women (HR 0.89, 95% CI: 0.66-1.2, P = 0.47).

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      High BMI is associated with improved outcomes in advanced NSCLC, primarily in men.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      The authors.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.