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  Lunch & Poster Display session (ID 58)

  • Event: ELCC 2019
  • Type: Poster Display session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1

  • 29038

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    80P - High blood platelets levels (BPL): A prognostic factor in patients with early or locally advanced non-small cell lung cancer (NSCLC) (ID 543)

    12:30 - 13:00  |  Author(s): ANTONIETA Salud
    • Abstract
    • Slides

    Background
    

    Patients with high blood platelets levels (BPL) have been reported to attenuate the efficacy of platinum-based chemotherapy and to have a worse prognosis when treated with surgery and postoperative adjuvant chemotherapy. This study describes a series of sample tumors from patients with clinically confirmed lung cancer.

    a9ded1e5ce5d75814730bb4caaf49419 Methods
    

    In all non-small cell lung cancer (NSCLC) patients diagnosed in the University Hospital of Lleida from January 2011 to December 2016, a real world data study of blood platelets levels (BPL) was performed. Each patient’s clinical history, pathology specimens and molecular results were noted. Four hundred and forty-five patients with low BPL formed the control group.

    20c51b5f4e9aeb5334c90ff072e6f928 Results
    

    The blood platelet levels (BPL) was analyzed in seven hundred and seventy-five (775) patients with an average of 290 mcL (24 - 995). In 330 patients (42%) a platelet level greater than 290 mcL was observed (22,1% females). The media age was 67 years. The smoking history was as follows: 57,2% former, 31,5% ex smokers and 11,2 never smokers. The clinical stages and histology were as follows: stage I and II: 17%, stage III: 30% and stage IV 53%; 43% of patients had adenocarcinoma histology, 36% squamous and 21% other. In patients treated with radical intention (surgery or chemotherapy plus radiotherapy) the median overall survival was 49 vs 36 months in patients with BPL ≥ 290 mcL (P = 0,00001), when they were compared with the control group, patients with high BPL (≥ 290 mcL) had overall shorter survival (P = 0,00001), regardless of histology, age or smoking history.

    fd69c5cf902969e6fb71d043085ddee6 Conclusions
    

    Patients treated with radical intention and high BPL (≥ 290 mcL), have worse overall survival, regardless of histology, age or smoking history.

    b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study
    

    The authors.

    213f68309caaa4ccc14d5f99789640ad Funding
    

    Has not received any funding.

    682889d0a1d3b50267a69346a750433d Disclosure
    

    All authors have declared no conflicts of interest.

    cffcb1a185b2d7d5c44e9dc785b6bb25

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