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Sergey S Pirogov

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      76P - Endobronchial surgery and photodynamic therapy for early central lung cancer treatment (ID 573)

      12:30 - 13:00  |  Presenting Author(s): Sergey S Pirogov

      • Abstract


      Development of endoscopic therapeutic methods for early central lung cancer.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      During the period from 1984 to 2019 in P.A.Hertsen Moscow Research Oncologic Institute has accumulated clinical experience in endoscopic diagnostics and treatment of early central lung cancer in 129 patients (176 tumors). X-Ray negative ECLC was observed in 86% of cases. As a treatment approach - electrocoagulation was in used from 1984 to 1993 in 73 patients (91 tumors) with ECLC, PDT and argon plasma coagulation (APC) were used from 1992 to 2019 in 56 patients (85 tumors). The following agents for used for PDT: radachlorine, photohem, photosense photolon. Endoscopic methods in 90% of cases was selected due to unfeasibility of the conventional surgery.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      In the group of patients with ECLC treated by electrocoagulation the complete tumor regression was observed in 89% of cases. The tumor recurrence observed only in 17% of cases. In the patients who received PDT and APC the results were determined by the tumor size. When the tumor size was not greater than 1 cm, complete regression was achieved in 100% of cases. When the tumor size ranged from 1 to 1.5 cm complete resorption was achieved in 75% of cases. and with the tumor size up to 2.5 cm complete regression was achieved in 29% of cases. In 9% of cases the recurrences were diagnosed. Follow-up period lasted up to 15 years. Median survival was 5.05 years. Five year survival rate was 50±12 %.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      Intraluminal endoscopic treatment methods - photodynamic therapy and argon-plasma coagulation in early central lung cancer patients, declined of conventional surgery, provides complete tumor regression in most of cases. 5-year disease-free survival achieved in half of patients group.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      The authors.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.