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Zhengwei Dong

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    P3.04 - Immunooncology (Not CME Accredited Session) (ID 970)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.04-05 - Programmed Death-Ligand 1 of Cytology Specimens as a Promising Method for Maker Evaluation in Patients of Non-Small Cell Lung Cancer (ID 13123)

      12:00 - 13:30  |  Presenting Author(s): Zhengwei Dong

      • Abstract
      • Slides


      Measuring programmed death-ligand 1 (PD-L1) expression has been commonly used to classify the promising patients for immunotherapy. PD-L1 heterogeneous expression has been elucidated within the tumor. Therefore, we questioned whether small tissue samples, such as cytology samples, sufficiently represented PD-L1 expression in non-small cell lung cancer(NSCLC).

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Paired cytological cell block and surgical resection before systemic therapy was assessed. PD-L1 expression was quantified by using both 28-8 and SP142 assays. Feasibility of PD-L1 expression in cell blocks was compared with that in matched surgical resection with various cutoffs.

      4c3880bb027f159e801041b1021e88e8 Result

      A total of 112 pairs of specimens were collected at the time of initial diagnosis, including 79(63.2%) adenocarcinomas and 28(25.0%) squamous cell carcinomas. PD-L1 expression showed fair to substantial concordance between cytology specimens and surgical resection for both antibodies’ staining ( 8eea62084ca7e541d918e823422bd82e Conclusion

      PD-L1 expression of cytology specimens with high tumor cells showed concordance with surgical resection. These findings suggested that cytology specimens might be adequate representative for PD-L1 expression of patients with NSCLC.


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