Author of

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  P1.03 - Biology (Not CME Accredited Session) (ID 935)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall

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    P1.03-25 - The Frequency and Prognosis of ATM Mutations in Chinese Non-Small-Cell Lung Cancer Patients (ID 11113)

    16:45 - 18:00  |  Author(s): Chuanjun Han
    • Abstract
    • Slides

    Background
    

    The ataxia-telangiectasia mutated kinase protein (ATM) plays a critical role in the cellular response to double strand DNA damage. While the genetic locus of ATM mutation NSCLC patients is unclear. The aim of this study is to investigate mutations and prognosis of NSCLC harboring ATM mutations.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 389 patients with non-small-cell lung cancer were recruited between July 2012 and December 2015. The status of ATM mutation and other genes were detected by next generation sequencing.

    4c3880bb027f159e801041b1021e88e8 Result
    

    ATM gene mutation rate was 6.17% (24/389) in non-small cell lung cancer, including L229V (1 patient), V2298E (1 patient), M2041V (1 patient), D126N (1 patient), S2123N (1 patient), Q95L (1 patient), R337H (1 patient), H1474R (1 patient), R772Sfs*25 (1 patient), W488L (1 patient), M1064T (1 patient), E347A (1 patient), K1192R (1 patient), P1374S (1 patient) R248* (1 patient), M1321I (1 patient), I346N (1 patient), H2430R (1 patient), G494D (1 patient), N2282S (1 patient), A1945S (1 patient), E518* plus D1616V (1 patient), Q161* plus E699Q (1 patient) and D2448G plus L2261Tfs*12 (1 patient), and median overall survival (OS) for these patients was 18.0 months. Among them, all patients were ATM gene with co-occurring mutation. Briefly, patients with (n=8) or without (n=16) co-occurring EGFR mutations had a median OS of 21.0 months and 11.0 months respectively (P=0.19); patients with (n=13) or without (n=11) co-occurring TP53 mutations had a median OS of 21.0 months and 14.0 months respectively (P=0.44).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Although EGFR and TP53 gene accompanied may have less correlation with ATM mutation in NSCLC patients, predict which patients may harbor ATM mutations, could have implications in triaging toward ATM variant identification for potential future targeted therapy. These data have implications for the identification of therapeutic target candidates .

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