Author of

• 25907

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  OA11 - Thymic and Other Thoracic Tumours: Targeted Therapies, Biomarkers and Neo/Adjuvant Radiotherapy (ID 919)

  • Event: WCLC 2018
  • Type: Oral Abstract Session
  • Track: Thymoma/Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 13:30 - 15:00, Room 205 BD

  • 26085

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    OA11.01 - Role of Post-Operative Radiation in Different Histologic Subgroups of Thymoma: Result Based on National Cancer Data Base (NCDB) (ID 14353)

    13:30 - 13:40  |  Author(s): Tarun Podder
    • Abstract
    • Presentation
    • Slides

    Background
    

    Thymoma and thymic carcinoma are rare neoplasms that occur in the anterior mediastinum. According to WHO classification, thymomas are classified into 5 different subgroups based on their clinical behavior. The role of post-operative radiation (PORT) has been studied well based on the stage grouping. However, the benefit of PORT on different histologic subtypes is not well defined. We analyzed role of PORT in 5 different subgroups of thymomas using NCDB data base.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    From 2004-2014, using C37.9 topographic code, 6532 patients were identified with a diagnosis of thymoma or thymic carcinoma. The median age was 60 years. 48.6% were male. 78.5% (n=5127) patients underwent surgery and 52.4% (n=3425) did not receive any radiation. Patients with no surgery and with thymic carcinoma histology were excluded. Patients with thymoma who had radiation dose between 40-60 Gy were included for the final survival analysis. Overall survival (OS) was calculated using Kaplan Meier method with log rank test for comparison analysis. IBM SPSS (v24) was used for statistical analysis; p-value of <0.05 was considered statistically significant.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Thymic carcinoma was the most frequent subtype (20.6%) followed by AB subtype (14.4%). Type A was least frequent subtype (7.7%) while 22.3% did not have any subclassification. 48.1% (n=3139) had no residual cancer, 12% had microscopic involvement and 2.6% had macroscopic residual cancer. Macroscopic tumors were more frequently seen with thymic carcinoma (3.43%) and B1 (1.23%), B3 (1.43%) subtypes. Median overall survival with surgery was 8 years compared to approximately 10 years with PORT (p<0.0001) for the entire group. Among 5 subcategories, PORT was associated with improved OS for type A (p<0.007), AB (p=0.008) and B3 (p=0.003). For B1, PORT was associated with inferior OS and for B2, PORT was not significant for OS.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    In this analysis PORT was associated with statistically significant improved OS in A, AB and B3 subgroups but not for B2 and B3. Further work is underway to perform multivariable analysis.

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