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Poster Display session (Friday) (ID 65)
- Event: ELCC 2018
- Type: Poster Display session
- Presentations: 1
- Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
210P - Brain oligometastases in NSCLC: Therapeutic effect and prognostic factors of WBRT combined with intracarotid infusion of elemene (ID 236)
12:30 - 13:00 | Presenting Author(s): Y. XU
To retrospectively analyze the curative effect of WBRT combined with intracarotid infusion of elemene following intracranial local treatment in NSCLC patients with brain oligometastases and investigate the related factors affecting the prognosis of patients.
Clinical data of patients admitted in the Affiliated Hospital of Dalian Medical University between Jan. 2000 and Dec. 2015 were collected. Inclusion criteria: (1) pathologically diagnosed as NSCLC; (2) brain metastasis confirmed by enhanced MR, with 1–3 lesions; (3) no metastases found in other parts of the body; (4) primary pulmonary lesions were effectively treated; (5) surgery or SRS were performed for intracranial lesions. Patents in the observation group were treated with WBRT alone with a dose of 40Gy/20f; and those in the study group were treated with the same WBRT scheme as the observation group, and 1000 mg elemene was infused daily for 15–20 days.
Forty-one patients had complete follow-up data. There were 22 males and 19 females, with the median age of 58 years; age >60 years in 17 cases and ≤60 in 24 cases; KPS score of 60 in 6 cases and KPS >60 in 35 cases. Followed the local treatment, 17 patients were treated with WBRT alone and 24 with WBRT combined with elemene. The median OS of all patients was 16.1 months and the median iPFS was 12 months. The 1- and 2- year survival rates were 68.2% and 24.4%, respectively. The median OS of the WBRT group and WBRT combined with elemene group were 14.8 and 18 months (χ2 = 2.328, P = 0.127) and the median iPFS was 10.3 and 13.8 months (χ2 = 4.010, P = 0.045), respectively. KPS > 60, single brain metastases, extracranial lesion control and the use of targeted therapy were the predictive factors for a good prognosis and multivariate analysis indicated that single brain metastases, extracranial focus control and targeted therapy were the independent prognostic factors for a favorable prognosis.
WBRT combined with intracarotid infusion of elemene can prolong the median iPFS of NSCLC patients with brain oligometastases. Single brain metastasis, extracranial lesion control and targeted therapy are the independent prognostic factors for a favorable prognosis.
Clinical trial identification:
Legal entity responsible for the study:
The First Affiliated Hospital of Dalian Medical University
Has not received any funding
All authors have declared no conflicts of interest.