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S. Seber

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    P1.01 - Advanced NSCLC (ID 757)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P1.01-029 - Lymphocyte Monocyte Ratio as a Prognostic Factor in Non Small Cell Lung Cancer (ID 8448)

      09:30 - 16:00  |  Author(s): S. Seber

      • Abstract
      • Slides

      Chronic state of inflammation is an important factor in advanced cancer which is used by tumor cells for maintaining survival and growth. Hematological parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/ lymphocyte ratio (TLR) and lymphocyte / monocyte ratio (LMR) are reliable indicators of systemic inflammation. We aimed to elucidate the effect of hematological parameters and clinical features of patients on the prognosis of advanced stage non-small cell lung cancer (NSCLC) .

      We included 102 stage IV NSCLC patients who presented to the oncology clinic between 2010-2016. Pretreatment clinical parameters and NLR, TLR, and LMR were retrieved from the medical records. The cut off values, calculated with ROC analysis, for NLR, LMR , TLR were 2.5, 3 and 183 , respectively. All patients were divided into two groups according to cut off values and analyzed accordingly.

      Median OS and PFS were 10 and 6 months respectively. In univariate analysis high NLR, high TLR and low LMR were found to be significantly associated with survival . Among clinical parameters having ECOG performance score 0-1 , older age (≥70 years ) single metastatic disease were prognostic. In multivariate cox regression analysis only the number of metastatic lesions and LMR were found to be independent predictors for survival.

      Although the interaction between tumor cells and the host immune system is a very complex process, LMR, NLR and TLR are hematological parameters that can be easily derived from total blood counts and can be used in daily clinical practice. Among these markers, we suggest that LMR holds the greatest potential as a viable prognostic factor in the setting of metastatic NSCLC.

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