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Carolina Gabay
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P1.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 692)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.06-021 - Lung Cancer Among Women Assisted in an Argentinean University Institution (ID 10270)
09:30 - 16:00 | Presenting Author(s): Carolina Gabay
- Abstract
Background:
Lung cancer remains the leading cause of cancer death worldwide and is responsible for 20,000 deaths yearly in Argentinean women. Despite prevention strategies the incidence of lung cancer in women in our population has not been decreasing. We described the clinicopathological and epidemiological profile of women diagnosed with lung cancer in our institution in the last seven years
Method:
A retrospective cohort of women with lung cancer diagnosis from the data base of the Thoracic Oncology Unit was reviewed
Result:
From 2010 to 2017, a total of 185 women with lung cancer were included. Median age was 61 (30-92). Distribution by age group was: ≤30: 1 (0.5%), 31-39:6 (3.2%), 40-49: 17 (9.2%), 50-64: 87 (47%), ≥65: 74 (40%).Histologic subtypes were: adenocarcinoma (77.3%, n=143), squamous cell carcinoma (13%, n=24), small cell lung cancer (5.9%,n=11), NOS (2.2%, n=4), large cell carcinoma (1.1%, n=2), and large cell neuroendocrine cancer ( 0.5%, n=1). Most women were smokers (70.8%, n=131)(mean 24.52±29.84 pack/year) and presented with and advanced disease (III-IV)(75%, n=139). Twenty eight women (15%) had history of other cancer (36% breast cancer and 21% cervix cancer).EGFR mutationand ALK rearrengements were identified in 26(14%) and 8 (4.3%)patients, respectively. Uncommon EGFR mutations like G719X in exon 18 (4/12, 33%) were observed in smokers (46%, 12/26). We also detected compound mutation patterns in 2 cases (1.9%)(G719X+L861Q and del19+T790M). Median OS for all patients was 25 months (95% CI 21.53-28.46), whereas for patients at stage III-IV was 20 months (95% CI 21.53-28.46). The independent factors associated with the OS were the ECOG PS, disease stage and the presence of symptoms at diagnosis.
Conclusion:
Women with lung cancer assisted in our institution showclinical and epidemiologic characteristics previously described in western population. However, we observed a relatively high proportion of EGFR mutations in smokers. Prospectively collected data will explore molecular and epidemiologic items in this subgroup of patients.
