Author of

• 20167

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  P2.03 - Chemotherapy/Targeted Therapy (ID 704)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Chemotherapy/Targeted Therapy
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23317

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    P2.03-046 - Lymhocyte-To-Monocyte Ratio and Mean Platelet Volume as Prognostic Factor in EGFR Mutant NSCLC Treated with EGFR TKI (ID 9738)

    09:30 - 16:00  |  Presenting Author(s): Kousuke Watanabe
    • Abstract
    • Slides

    Background:
    EGFR mutation is a strong predictor of the response to EGFR-TKI, but 10-30% of EGFR-TKI naive patients do not respond to the first line EGFR TKI therapy. Inflammation plays an important role in the initiation, progression, invasion and metastasis of cancer. Recentry study has demonstrated that hematological markers of inflammation such as LMR (lymphocyte to monocyte ratio), RDW (red cell distribution width), and MPV (mean platelet volume) are valuable biomarker in various types of human cancers. The purpose of the present study is to analyze whether hematological markers of inflammation is a prognostic factor in EGFR mutant NSCLC treated with EGFR TKI.
    
    Method:
    We retrospectively analyzed 75 advanced or recurrent NSCLC patients with common EGFR mutation treated with EGFR-TKI between 2008 to 2017 at the University of Tokyo hospital. Patients with de novo T790M mutaion, systemic corticosteroids or active infection were excluded from the analysis. We analyzed whether the hematological markers of inflammation before the TKI therapy impact the PFS of TKI therapy. The following variables were included: LMR, RDW, MPV, EGFR mutation subtype (Exon19 deletion of L858R) , ECOG performance status, age and gender. The PFS was estimated by the Kaplan-Meier method and were compared by the log-rank test. Prognostic factors for PFS were assessed by Cox’s proportional hazards regression model. Statiscital analysis was performed using the survival package in the R software.
    
    Result:
    Low LMR and high MPV were associated with shoter PFS (log-rank test, p=0.000057 and p=0.03 respectively), but RDW was not associated with PFS. In the multivariate analysis, low LMR (hazard ratio (HR) 2.9; p=0.00015), high MPV (HR 1.7; p=0.039), and poor PS (HR 2.0; p=0.046) were independent risk factors for shoter PFS.
    
    Conclusion:
    Low LMR and high MPV are independent risk factors for shorter PFS in patients treated with EGFR-TKI.
    
    

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