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I. Pavlovska

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    P1.01 - Poster Session with Presenters Present (ID 453)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Epidemiology/Tobacco Control and Cessation/Prevention
    • Presentations: 1
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      P1.01-014 - The Role of Hereditary Factor, Profession and the Habit of Cigarette Smoking in Developing Lung Cancer (ID 3977)

      14:30 - 15:45  |  Author(s): I. Pavlovska

      • Abstract
      • Slides

      Lung cancer (LC) is the most common and deadliest cancer in the world. In the Republic of Macedonia, within the period 2002-2012, the LC took the first place according to the frequency of appearing in men, while it was on the fourth place in women. The number of the risk factors is great being connected with the occurrence of LC. The aim of this study was to analyze the role of genetic factor, professional exposure and the habit of cigarette smoking in occurrence of lung cancer.

      The research was conducted as a case-control study. It included 185 patients diseased of LC (investigated group-IG) and the same number of persons without malignant disease (control group-CG). In the study were included only interviewees with pathohistologically confirmed LC. Through calculating the risks of the Odds ratio (OR), the risk-factors, which had a role in occurrence of the disease, were quantified, while with the Confidence intervals (CI), the statistical significance for the error level less 0,05 (p) was defiend.

      According to the investigation results, malignant disease of two members in one family was found in 13,5% of the IG, 9,4% of the CG, respectively. Current smokers (CS) with present hereditary factor had almost 4 times (OR=3,95; 95%CI, 1,78-8,77), greater risk to become ill compared to the never smokers (NS) without hereditary factor. The risk was greater when the same would be compared to the NS with present hereditary factor (OR=8,76; 95%CI, 1,80-42,68).In the diseased, the professional exposition was present in 68,6% from IG, versus 67% in the CG. The highest risk for LC was found in transport workers (OR=2,50;95%CI, 1,01-6,15) and automehanics (OR=2,31;95%CI, 0,76-7,07). CS represented 67% of diseased individuals versus 40,5% of the CG. The risk for them to develop LC was 5,54 (95%CI, 3,0-10,23), times significantly greater compared to the NS. The risk for the disease was significantly greater in individuals who were smoking >20years (y), >20cigarettes/day (c/day), compared to those, who, in the same time period, smoked <20c/day (OR=3,78;95%CI, 2,04-7,01). The risk to develop LC in former smokers (FS), who >20y smoked >20c/day was 2,40 (95%CI, 0,94-6,14), times greater compared to those, who smoked >20y, <20c/day.

      This disease developed twice more commonly in the examined individuals, exposed to professional carcinogens. The LC is multifactor disease for which development, besides smoking, as a main determinant, in mutual interaction are the genetic and other factors of the surrounding and the way of living.

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