Author of

• 13580

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  P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13620

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    P1.04-040 - Stage I Adenocarcinoma According to the 2011 IASLC/ ATS/ ERS: Case Series from Brazil (ID 3145)

    09:30 - 17:00  |  Author(s): R.P.C. Sapucaia
    • Abstract

    Background:
    Lung cancer is the deadliest cancer worldwide and it is of particular concern in Brazil as the second cause of cancer death in both genders. The new classification proposed by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification has proven its prognostic value with also a better clinical understanding of lung adenocarcinoma. Prior to this classification all patients diagnosed with early stage adenocarcinoma were considered to have practically the same disease. In our country, however, medical literature is still incipient on this topic. We reviewed the histopathology of a consecutive series of patients diagnosed with stage I adenocarcinoma.
    
    Methods:
    Cross-sectional study including 50 patients diagnosed with stages IA or IB adenocarcinoma undergoing surgical resection of non-small cell lung cancer. The variables: histological subtype, sex, age and tumour size. We have divided patients in two groups based on the presence of lepidic features. Statistical analysis was performed by Anova and Bonferroni multiple comparison test, to correlate tumour size among histological subtype groups.
    
    Results:
    The mean age was 63.7 (11.5) years, 50% were men. The average size of resected tumours was 1.4 (0.7) mm; 45 cases (90%) were stage IA. The predominant subtypes were histologically lepidic (n=24, 48%); the acinar subtype was found in 20 (40%) cases. Patients and tumour characteristics according to histological subtype are showed in table 1. There was statistical difference in size (p<0.05) when comparing lepidic tumors with acinar tumors (1.3mm versus 2.3mm respectively). Table 1: Patients and tumour characteristics according to histological subtype.

    Subtypes Variables	Lepidid	Acinar	Others	p
    n (%)	24 (48)	20 (40)	6 (12)
    Men n (%)	11 (45.8)	9 (45)	6 (100)
    Age mean (SD)	63 (11.6)	66.3 (10.8)	62.7 (7.7)
    Tumor size mean (SD)	1.3 (0.6)	2.3 (1.4)	1.6 (0.6)	0.02*

    *Anova with Bonferroni multiple comparison test.
    
    Conclusion:
    In our brief series of lung adenocarcinoma patients, the most common subtypes were acinar and lepidic; the latter being larger in this sample. The long-term follow-up will give us important information about the prognosis of these patients treated exclusively with surgery.