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Minhua Ye
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P01 - Antibody Drug Conjugates, Novel Therapeutics and Cytotoxics (ID 227)
- Event: WCLC 2020
- Type: Posters
- Track: Antibody Drug Conjugates, Novel Therapeutics and Cytotoxics
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P01.20 - Short-Term Effificacy of Intrapleural Hyperthermic Perfusion for Malignant Pleural Effusion in Lung Carcinoma (ID 1974)
00:00 - 00:00 | Presenting Author(s): Minhua Ye
- Abstract
Introduction
Malignant pleural effusion (MPE) has a poor prognosis. Most patients are treated with tube thoracostomy and sclerotherapy, although its success rate is around 64%. We have investigated Intrapleural hyperthermic perfusion for MPE.
Methods
In this retrospective study, thirty-one patients with MPE was performed by perfusing the pleural cavity with 43.0 °C saline solution using a devised circuit through mechanical circulation for 60 minutes.
Results
From January 2014 through November 2018, we performed this technique in 31 patients with MPE. There were no serious clinical complications associated with this procedure. The pleural effusion was well controlled in 96.6% of the patients. The median survival time was 12 months in all patients, with a one-year survival rate of 54.8%. The 1-year and 2-year survival rates for EGFR positive lung adenocarcinoma patients were 54.8% and 16.1%҅EGFR negative were 38.4% and 15.4%. The 1-year and 2-year survival rates for M1a non-N2 were 78.6% and 23% M1a N2 were 41.7% and 8.3%.
Conclusion
Intrapleural hyperthermic perfusion seems to have considerable value as an adjuvant therapy for patients with pleural dissemination who have had MPE caused by lung carcinoma.
