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Wei Dai
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P32 - Palliative and Supportive Care - Misc. Topics (ID 220)
- Event: WCLC 2020
- Type: Posters
- Track: Palliative and Supportive Care
- Presentations: 2
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P32.04 - Preoperative Self-Reported Symptom Burden and Quality of Life of Patients Undergoing Lung Cancer Surgery: A Cross-Sectional Study (ID 2768)
00:00 - 00:00 | Presenting Author(s): Wei Dai
- Abstract
Introduction
In today's era when minimally invasive thoracoscopic surgery is the mainstream, the symptom burden and quality of life of lung cancer patients before surgery is unclear. We aimed to investigate the preoperative self-reported symptom burden and quality of life of patients with lung cancer.
Methods
We used the MD Anderson Symptom Inventory-lung cancer module (MDASI-LC) and the single-item quality of life scale (UNISCALE) to collect the preoperative patient-reported outcomes of 396 patients with lung cancer from November 2017 to November 2019 in 6 tertiary hospitals in China. Descriptive statistics were used to summarize the patient's demographics, clinical factors, and self-reported data. Comparison was performed in demographics and clinical factors.
Results
Of 396 patients, 90.2% reported preoperative symptoms. The 6 most common symptoms were coughing (63.2%), dry mouth (53.0%), disturbed sleep (51.0%), difficulty remembering (49.2%), drowsiness (41.3%) and fatigue (39.7%). The 6 most common moderate to severe symptoms were disturbed sleep (22.6%), distress (16.1%), difficulty remembering (15.1%), coughing (15.0%), dry mouth (14.2%) and sadness (13.0%). Patients with adenocarcinoma had milder lack of appetite and coughing before surgery (P < 0.05). Patients with early-stage lung cancer had less pain, fatigue, lack of appetite, drowsiness and coughing (P < 0.05). The median quality of life score is 8 (4.0). Symptom score was positively correlated with symptom interference with life score (r = 0.63, P < 0.01) and negatively correlated with quality of life score (r = – 0.37, P < 0.01).
Conclusion
Most patients with lung cancer have a mild symptom burden before surgery. The most frequent and most common moderate to severe symptoms are coughing, dry mouth, difficulty remembering and disturbed sleep. Patients with early-stage lung cancer have a milder symptom burden.
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P32.06 - Investigation of the Current Use of Opioid Analgesics After Lung Resection and the Analysis of Its Influencing Factors (ID 3359)
00:00 - 00:00 | Author(s): Wei Dai
- Abstract
Introduction
The use of opioid analgesics after lung resection is unclear in China. This study aimed to investigate the current use of opioid analgesics after lung resection and analyseits influencing factors.Table 2.Analgesic information
Name of analgesics
Number
Percentage
Opioids
448
99.6%
Weak opioids
38
8.4%
Codeine tablets
3
0.7%
Codeine oral liquid
37
8.2%
Strong opioids
437
97.1%
Morphine hydrochloride tablet
0
0%
Fentanyl transdermal patch
0
0%
Oxycodone hydrochloride sustained release tablets
2
0.4%
Morphine Sulfate Sustained-release Tablets
5
1.1%
fentanyl
0
0%
Sufentanil
323
71.8%
Remifentanil
70
15.6%
morphine
74
16.4%
Oxycodone
0
0.0%
Butorphanol
311
69.1%
Dezocine
206
45.8%
Bucinazine
29
6.4%
Pethidine
0
0%
Compound
369
82.0%
Lofenadine sustained release tablets
369
82.0%
Methods
The clinical data of 450 patients undergoing lung resection at Sichuan Cancer Hospital from November 2017 to November 2019 were analysed retrospectively. Various opioid analgesics were converted into oral morphine milligram equivalents. Multiple linear regression was performed to determine its influencing factors.
Results
Of the 450 patients, 448 (99.56%) used opioid analgesics; 8.4% used weak opioids, 97.1% used strong opioids and 82% used compoundanalgesics.The mean daily morphine equivalent dose during hospitalization was 48.9 mg. There were significant differences in postoperative morphine equivalent dose across patients with different sex, age,operative time,length of hospital stay, educational level, comorbidity score, surgical approach, surgical extentand postoperative complication grade (P< 0.05). Multivariate analysis showed that sex, length of hospital stay and surgical approach were independent influencing factors for postoperative morphine use.
Conclusion
This study provided a baseline reference for the use of opioid analgesics after lung resection in China. In clinical practice, attention should be paid to postoperative analgesia for male patients, to promote the application of minimally invasive surgical approach, and tominimize the length of hospital stay, in order to ultimately reduce the use of opioids.
