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Ilavarasi Vanidassane



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    P54 - Tumor Biology and Systems Biology - Basic and Translational Science - Carcinogenesis (ID 191)

    • Event: WCLC 2020
    • Type: Posters
    • Track: Tumor Biology and Systems Biology - Basic and Translational Science
    • Presentations: 1
    • Moderators:
    • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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      P54.04 - A Study to Determine the Association of Trace Eelments and Heavy Metals with Lung Cancer and their Correlation with Smoking (ID 3069)

      00:00 - 00:00  |  Presenting Author(s): Ilavarasi Vanidassane

      • Abstract
      • Slides

      Introduction

      Metal dyshomeostasis in lung cancer is not understood, whether it is due “causal effect” associated with tobacco or environmental exposure or due to the “effect” of the carcinogenesis process is not well known. There is scarce data on the association of heavy metals and trace elements in smoker and non-smoker lung cancer

      Methods

      A cross-sectional observational study on 100 lung cancer patients and 100 healthy controls ( 50 smokers and 50 non-smokers in each group ) from National Capital Region was conducted in the Department of Pharmacology and Medical Oncology at AIIMS, New Delhi from 2017 to 2019. The objective of the study was to determine the levels of arsenic, cadmium, chromium, nickel, copper, zinc, iron, lead in blood samples of lung cancer patients in comparison with healthy controls, and its correlation with smoking. The blood sample was stored and digested by microwave digestion system and trace elements estimation was Pastedone by Inductively Coupled Plasma mass Spectroscopy.

      Results

      Demographic parameters like age group, gender, and smoking index (more or less than 200) were comparable among both the groups. Lung cancer patients had statistically significant higher levels of all the seven metals in comparison to healthy controls irrespective of smoking status. The levels of heavy metals were higher in smokers when compared to non-smokers among lung cancer group and healthy controls. (Table 1) . Within the lung cancer group, only nickel was significantly higher in smokers with lung cancer when compared to non-smokers (83.8 µg/dl vs. 28.2 µg/dl, p-<0.01). There was a significant positive correlation of Cd, Pb, Cr, As, Zn, Cu, Ni with the smoking index in the entire study population.

      Metal values in lung cancer and control subgroups.
      Metal levels

      LC-NS

      (n-50)

      C-NS

      (n-50)

      LC-S

      (n-50)

      C-S

      (n-50)

      		 P-value

      LC vs.C

      (NS)

      LC vs. C

      (S)

      C -S

      Vs C -NS

      LC-NS

      Vs

      C-S

      LC-S

      Vs LC- NS

      Cd μg/dL

      Median

      Min- Max

      2.9

      0 – 37

      0.02

      0-13.72

      2.2

      0-36.71

      0.4

      0- 7.6      		 0.001 0.001 0.002 0.001 0.01 1.00

      Cr μg/dL

      Median

      Min- Max

      178.1

      79.7-568.3

      5.5

      0.7 -229.2

      188.4

      61.0-433.8

      83.4

      4.8-165.7      		 0.001 0.001 0.001 0.001 0.001 1.00

      Pb μg/dL

      Median

      Min- Max

      12.5

      3 -960.6

      0.7

      0-76

      22.4

      2.9-3544.5

      8.6

      0.7-23.8      		 0.001 0.001 0.001 0.001 0.006 1.00

      As μg/dL

      Median

      Min- Max

      3.7

      0.9-10.5

      0.2

      0.1-6.7

      3.0

      1.8- 138.9

      2.5

      0.3- 5      		 0.001 0.001 0.001 0.001 0.001 1.00

      Zn μg/dL

      Median

      Min- Max

      733

      336.7- 1057.3

      32.1

      11.4- 992.9

      720.9

      216.4 -35254.1

      375.7

      32.3-1361.8      		 0.001 0.001 0.001 0.001 0.001 0.97

      Cu μg/dL

      Median

      Min- Max

      260.9

      79.4 - 501.8

      19.5

      5.7-333.2

      267.2

      63.6 - 71229.4

      105

      14.6 -252.8      		 0.001 0.001 0.001 0.001 0.001 1.00

      Ni μg/dL

      Median

      Min- Max

      28.22

      0-273.2

      10.2

      0- 53.1

      83.8

      31.3- 831.3

      18

      5.6- 85.67      		 0.001 0.001 0.001 0.002 0.001 0.01
      LC-NS : lung cancer non smokers, C-NS : control non smokers, LC -S : lung cancer smokers, C-S control smokers, Cd cadmium , Cr- chromium , Pb : lead, As: arsenic, Zn: Zinc, Cu: copper , Ni : Nickel.

      Conclusion

      The study confirms the association of raised heavy metals in lung cancer patients. Higher metal levels in non-smoker lung cancer patients in comparison to smoker control strongly suggest carcinogenesis-related factors may be involved in dyshomeostasis of metal levels in lung cancer irrespective of smoking status. Nickel was significantly raised in smokers with lung cancer when compared to non-smokers. Further study to find the relationship between metallothioneins and metal levels may help in establishing the cause-effect relationship of heavy metals and lung cancer

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