Author of

• 35710

  +

  MA09 - Prognosis and Staging (ID 187)

  • Event: WCLC 2020
  • Type: Mini Oral
  • Track: Staging
  • Presentations: 1
  • Moderators:
  • Coordinates: 1/31/2021, 09:15 - 10:15, Scientific Program Auditorium

  • 35714

    +

    MA09.06 - The Influence of the Number of Lymph Nodes Removed on the Accuracy of a Newly Proposed N Descriptor Classification in Patient with NSCLC (ID 3179)

    09:15 - 10:15  |  Presenting Author(s): Dariusz Dziedzic
    • Abstract
    • Slides

    Introduction
    

    The International Association for the Study of Lung Cancer has proposed a new classification of N descriptor based on the number of metastatic lymph nodes (LNs) stations, including skip metastasis. The aim of the study was to determine the effect of removed LNs on the adequacy of this new classification.

    Methods
    

    The material was collected retrospectively based on the database of the Polish Lung Cancer Group, including information on 8016 patients with non-small cell lung cancer operated in 23 thoracic surgery centers in Poland. The material covered the period from January 2005 to September 2015. We divided patients into two groups: ≤6LNs and >6LNs removed.

    Results
    

    In the whole group, an average of 13.4 nodes and 4.54 nodal stations were removed. 5-year survivals in the >6LNs group vs ≤6LNs group were: 62,3% and 55,1% (N0), 44,5% and 35,9% (N1a), 34,1% and 31,7% (N1b), 37,3% and 26,3% (N2a1), 32,4% and 26,7% (N2a2), 29,4% and 29,2% (N2b1), and 22,0% and 23,0% (N2b2), respectively. Comparing these groups, we detected significant differences at N0 (p<0.001) and N2a1 (p=0.022). In the ≤6LNs group, the survival curves for N2a1, N2a2, N2b1, and N2b2 overlapped (p>0.05). In the >6LNs group, the survival curves were significantly different between grades, with survival for N2a1 better than N1b (p=0.232).

    Conclusion
    

    The proposed classification N descriptor is potentially better at differentiating patients into different stages. The accuracy of the classification depends on the number of lymph nodes removed. Therefore, the extent of lymphadenectomy has a significant impact on the staging of surgically-treated lung cancer.

    Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.