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Erjia Zhu

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    P52 - Staging - Prognosis and Staging (ID 186)

    • Event: WCLC 2020
    • Type: Posters
    • Track: Staging
    • Presentations: 1
    • Moderators:
    • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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      P52.01 - Lepidic Component Identifies a Subgroup of Lung Adenocarcinoma with a Distinctive Prognosis: A Chinese Population-based Multicenter Study (ID 2496)

      00:00 - 00:00  |  Presenting Author(s): Erjia Zhu

      • Abstract
      • Slides


      The aim was to investigate the prognostic value of the lepidic component in patients with lung adenocarcinoma (LUAD).


      We retrospectively investigated 1,719 surgically resected LUAD samples classified as p-stage T1a-T2N0M0 according to the eighth edition of Lung Cancer Stage Classification.


      figure-1.jpgfigure-4.jpgOf the cases, 863 (50%) had a lepidic component. Multivariate analysis revealed that lepidic component presence was an independent prognostic factor for prolonged recurrence-free survival (RFS; P < 0.001) and overall survival (OS; P < 0.001). Furthermore, lepidic ratios (LR) > 50%, between 25% and 50% or ≤ 25% were confirmed to be independent prolonged survival predictors. No survival differences were observed among patients with LUAD with LR > 50%, between 25% and 50% or ≤ 25% (RFS, P = 0.342; OS, P = 0.256). When accounting for lepidic component presence, neither T stage nor pathological subtype was associated with the prognosis of LUAD with a lepidic component. The 5-year OS rates of patients with LUAD with a lepidic component were 90% regardless of the T stage or pathological subtype, and these survival rates were significantly better than those of patients with LUAD without a lepidic component in the corresponding T stage or pathological subtype.


      Lepidic component presence identifies a LUAD subgroup with an excellent prognosis independent of the LR, pathological subtype and pathological T classification. Considering lepidic component presence may improve prognostic predictions for patients with LUAD.

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