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Yiyuan Ao
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P42 - Screening and Early Detection - Risk Modelling and Artificial Intelligence (ID 177)
- Event: WCLC 2020
- Type: Posters
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P42.08 - Association Between the Age at First-Live Birth and Lung Cancer Risk: Meta-Analysis and Mendelian Randomization Analysis (ID 1921)
00:00 - 00:00 | Presenting Author(s): Yiyuan Ao
- Abstract
Introduction
Evidence about the role for reproductive factors in the etiology of lung cancer in women is conflicting. What’s more, the causality of such association is uncertain since conventional observational studies are easily influenced by confounders and inverse causation. Therefore, we carried out this meta-analysis and Mendelian randomization (MR) analysis in order to examine whether the age of first-live birth is associated with lung cancer risk.
Methods
Both meta-analysis and MR analysis were conducted in our study. For meta-analysis, a comprehensive search was performed in online database up to March 2020 and the risk of lung cancer was identified by calculating the relative ratios (RR) and its 95% confidence interval (CI). For MR studies, six relevant single nucleotide polymorphisms (SNPs) identified by latest genome-wide association studies (GWAS) were used as instrumental variables (IVs) in our study. Summary data of genetic information were obtained from three studies of the International Lung Cancer Consortium (ILCCO). Inverse-weighted (IVW) method was applied to estimate the causation between them.
Results
The results of meta-analysis showed women with older age at first-live birth (RR=0.93, 95%CI= 0.80-1.08, p=0.328) (Figure A) had a trend towards decreased risk of lung cancer without statistical significance. Furthermore, the results of IVW methods also demonstrated that older age at first-live birth of women was causally associated with decreased risks of both overall lung cancer (OR=0.82, 95%CI= 0.69-0.97, p=0.017) (Figure B) and adenocarcinoma (OR=0.75, 95%CI= 0.59-0.97, p=0.029). However, such association was not observed in squamous cell lung cancer (OR=0.77, 95%CI= 0.57-1.05, p=0.103).
Conclusion
Older age at first-birth of women seemed to be a protective factor for lung cancer, suggesting a role of reproductive factors in the development of lung cancer. Future studies on reproductive factors and lung cancer risk are warranted.
