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Margaret Hampshire



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    FP09 - Screening and Early Detection (ID 175)

    • Event: WCLC 2020
    • Type: Posters (Featured)
    • Track: Screening and Early Detection
    • Presentations: 1
    • Moderators:
    • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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      FP09.04 - Association Between Family History and Other Risk Factors for Lung Cancer: Analysis of an Internet-Based Risk Assessment (ID 1145)

      00:00 - 00:00  |  Author(s): Margaret Hampshire

      • Abstract
      • Slides

      Introduction

      While smoking and asbestos exposure are strongly associated with lung cancer (LC), associations between diet/obesity, alcohol consumption, and marijuana smoking have also been reported. Individuals with a family history (FH) of cancer are more likely to be smokers but are also more likely to be in contemplation/preparation stages of smoking cessation. The CDC recommends integrating FH of cancer into prevention and control programs. Current smokers appreciate that they are at an increased risk for LC; however, they do not appreciate the impact of FH and genetics on this risk. The association between FH of LC and behavioral risk factors for developing cancer is not well understood. While smoking cessation remains the most important preventive measure to reduce the risk of LC, mitigation of other behaviors may reduce the risk of LC and other cancer types as well.

      Methods

      The OncoLink Reduce My Risk tool is an Internet platform created in 2009 to provide personalized information regarding cancer risk, available at OncoLink.org. Voluntary participants were asked about risk factors and risk-associated behaviors. Differences between respondents with v. without FH of LC were analyzed using chi-square test.

      Results

      Among 28,001 respondents, 5,326 (19%) reported FH of LC. Those with FH of LC were more likely to be current cigarette and marijuana smokers and to smoke > 1 pack per day (Table). However, respondents with household income >$75,000 who had FH of LC were not more likely to be current smokers compared to those without FH (Table). Those with FH of LC were more likely to drink alcohol regardless of demographic factors, and to drink both 8+ and 11+ drinks per week (Table). Those with FH of LC were more likely to be obese regardless of demographic factors, and less likely to exercise 2+ times per week (Table). Those with FH of LC were more likely to have received 10+ imaging scans and to have been exposed to hydrocarbons compared to those without FH (Table). There were no reported differences in any other occupational or home exposures, including asbestos and radon in those with v. without FH of LC (Table).

      Family History (FH) of Lung Cancer and Associated Risk Factors and Demographics
      Behavior/Risk Factor Pos FH Neg FH P-value Behavior/Demographic Pos FH Neg FH P-value Behavior/Demographic Pos FH Neg FH P-value Behavior/Demographic Pos FH Neg FH P-value
      Current Smoker 15.3% 12.0% <0.001 Current Smoker Current Alcohol Obese
      > 1 Pack Per Day 4.9% 3.4% <0.001 Rural 17.6% 13.6% 0.001 Rural 51.1% 49.1% 0.2654 Rural 38.1% 28.6% <0.001
      Current Marijuana 13.6% 11.9% 0.003 Suburban 13.0% 9.6% <0.001 Suburban 61.2% 53.9% <0.001 Suburban 27.5% 22.8% <0.001
      Current Alcohol 59.6% 53.5% <0.001 Urban 17.9% 15.0% <0.001 Urban 62.5% 55.7% <0.001 Urban 26.2% 22.8% 0.016
      8+ Drinks/Week 23.3% 18.5% <0.001 $ 0 - 75,000 20.4% 15.3% <0.001 $ 0 - 75,000 56.6% 51.0% <0.001 $ 0 - 75,000 33.9% 28.9% <0.001
      11+ Drinks/Week 14.5% 11.3% <0.001 $75,000 + 9.8% 8.6% 0.082 $75,000 + 66.9% 62.5% <0.001 $75,000 + 26.5% 21.2% <0.001
      Obese 29.2% 23.8% <0.001 White 15.4% 12.5% <0.001 White 61.0% 57.3% <0.001 White 29.5% 24.2% <0.001
      Exercise 2+/Week 60.7% 65.1% <0.001 Non-White 12.4% 9.4% 0.057 Non-White 50.6% 41.3% <0.001 Non-White 27.7% 22.0% 0.028
      10+ Imaging Scans 9.0% 6.0% <0.001 < Full College 18.8% 14.3% <0.001 < Full College 51.7% 44.5% <0.001 < Full College 30.3% 24.2% <0.001
      Asbestos Exposure 1.5% 1.9% 0.417 College + 11.5% 9.4% 0.001 College + 68.1% 64.0% <0.001 College + 27.9% 23.3% <0.001
      Radon Exposure 4.2% 3.4% 0.101
      Hydrocarbon Exposure 3.4% 2.6% 0.001
      Heavy Metal Exposure 2.2% 2.0% 0.405
      Mustard Gas Exposure 0.3% 0.4% 0.698
      Industrial Dye Exposure 2.3% 2.2% 0.633
      Occup Radiation Exposure 1.3% 1.0% 0.782
      Conclusion

      FH of LC is associated with higher-risk behaviors that increase the likelihood of developing both lung and other cancers. As such, FH can be used in cancer prevention and control programs to identify higher-risk patients and educate patients that FH of lung cancer is associated with risk-increasing behaviors that are nonetheless modifiable.

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