Virtual Library

Start Your Search

Yanting Zhang



Author of

  • +

    OA10 - The Slow Pandemic – Tobacco Control in the Prevention of Lung Cancer (ID 170)

    • Event: WCLC 2020
    • Type: Oral
    • Track: Risk Reduction and Tobacco Control
    • Presentations: 1
    • +

      OA10.05 - Global Patterns and Trends in Lung Cancer Incidence: A Population-Based Study (ID 3090)

      10:30 - 11:30  |  Presenting Author(s): Yanting Zhang

      • Abstract
      • Presentation
      • Slides

      Introduction

      Lung cancer (LC) has been the most frequent cancer worldwide over several decades. Birth cohort effects represent generational changes in prevalence of causal factors, such as specific lifestyles or behaviors and environmental carcinogens. Period effects reflect changes in factors that simultaneously affect all individuals during a particular time period regardless of their individual differences, such as changes in diagnostic practices and the introduction of screening project. This study aimed to comprehensively examine the up-to-date geographical patterns and temporal trends in LC incidence from 1978 to 2012 for 43 countries across five continents, and evaluate the effects of birth cohort and period on the temporal trends to better identify populations at increased risk of LC and provides clues for understanding the causal factors underlying the changing trends.

      Methods

      Cancer registry data were retrieved from Cancer Incidence in Five Continents database. Joinpoint regression model was performed to examine the change of Age-standardized rates (ASRs) over time by average annual percent change (AAPC). Age-period-cohort model was conducted to detect the change of incidence rate ratios (IRRs) of birth cohort effect and period effect.

      Results

      Worldwide, 1.2 million (1,207,815) male and 0.7 million (714,751) female LC cases were diagnosed in 2008-2012, with ASR highest in Turkey (69.3 per 100,000 person-years) and in Denmark (36.7), respectively. Sex disparities were noted in almost all countries, with the male-to-female rate ratios exceeding 5.0 in 5 countries (Belarus, Turkey, Lithuania, Bulgaria and Estonia) and ranging from 2.0 to 5.0 in 22 countries. During 1978-2012, 19 countries showed significantly favorable trends among males, with the largest declines occurring in Bahrain (AAPC = -6.9), while 26 countries showed significantly unfavorable trends among females, with AAPCs ranging from 0.9 to 5.2. Birth cohort effects were statistically significant and stronger than period effects in 31 countries for males and in 29 countries for females. The quasi-reversed V-shaped and U-shaped trends in IRRs of birth cohort effect were detected in 26 countries for males and in 12 countries for females, with the highest risks mainly occurring in the 1930-1950 birth cohorts and in the 1930-1960 birth cohorts, respectively. However, the risks among recent generations have increased in China and Japan for males, and in Lithuania, Belarus and Republic of Korea for females. The increases of IRRs were steep among earlier birth cohorts and then decelerated for cohorts born since 1930-1950 in Denmark, Ireland, France, Germany, The Netherland, Croatia, Italy, Slovenia, Bulgaria, Slovakia, Ecuador, Japan, India, Israel (Jews) and Turkey for females. Period effects were more evident than birth cohort effects in United Kingdom, The Netherlands, US Black, Costa Rica and Republic of Korea for males, and in United Kingdom, Slovakia, China, India and Turkey for females.

      Conclusion

      Disparities in the incidence and carcinogenic risk of LC persist worldwide. The disparity in both incidence rates and trends of birth cohort effect between the sexes may reflect sex differences in underlying risk factors and pathogenesis. Further etiologic research will be required to identify reasons for the elevated incidence of LC among females.

      Only Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login, select "Add to Cart" and proceed to checkout. If you would like to become a member of IASLC, please click here.

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.