Author of

• 35377

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  P14 - Immuno-biology and Novel Immunotherapeutics (Phase I and Translational) - Immuno-Biology (ID 153)

  • Event: WCLC 2020
  • Type: Posters
  • Track: Immuno-biology and Novel Immunotherapeutics (Phase I and Translational)
  • Presentations: 1
  • Moderators:
  • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall

  • 35403

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    P14.16 - The Early Landscape of Immune Cell Subsets in Metastatic NSCLC Patients Treated with Immune Checkpoint Inhibitors (ID 2470)

    00:00 - 00:00  |  Presenting Author(s): Jianguo Zhou
    • Abstract
    • Slides

    Introduction
    

    Programmed cell death ligand 1 (PD-L1) has a low predictive power for treatment response to PD-1/PD-L1 immune checkpoint inhibitors (ICI). Recent biomarker research focuses on early immunological changes in the peripheral blood to predict treatment response to ICIs. We have aimed to detect the early landscape of immune cell subsets in non-small cell lung cancers.

    Methods
    

    Changes of 54 immune cell subsets of the peripheral blood of the patients were analyzed between the first and second administration of the ICI. Univariate and multivariate Cox proportional hazards regression analysis were used to identify the OS-related subsets.

    Results
    

    A total of 40 patients were prospectively enrolled and from 34 patients the immunophenotypes of whole blood samples were available for the analyses. No matter whether as continuous or categorical variables, 5 subsets of monocytes correlated significantly with OS (all P< 0.05): CD14^high/CD16^-/HLA-DR^high, CD14^high/CD16^-/HLA-DR⁺, CD14⁺/HLA-DR^high, CD14⁺/HLA-DR⁺, CD14^low/CD16^-. Four of them, expect of CD14^low/CD16^-, remained independent prognostic factors in multivariate analyses after adjusting for clinical and pathologic factors (all P< 0.05).

    Conclusion
    

    HLA-DR expressing monocytes in the peripheral blood are powerful predictors for advanced NSCLC patients who may benefit from ICI treatment.

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