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Yuanyong Wang
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P13 - Health Services Research/Health Economics - Misc. Topics (ID 219)
- Event: WCLC 2020
- Type: Posters
- Track: Health Services Research/Health Economics
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P13.01 - Analysis of the Effect of Personalized Nursing in Patients Undergoing Thoracoscopic Surgery for NSCLC (ID 1398)
00:00 - 00:00 | Presenting Author(s): Yuanyong Wang
- Abstract
Introduction
To analyze the effect of personalized nursing in patients with NSCLC undergoing thoracoscopic surgery.
Methods
NSCLC of 158 patients who underwent thoracoscopy were randomly divided into control group and observation group, with 79 cases in each group. Patients in the control group received routine nursing measures, and patients in the observation group received personalized nursing measures. The two groups of patients were compared for extubation time, hospitalization, the occurrence of complications, and nursing satisfaction.
Results
The time of extubation (38.3 ± 4.7)h and hospital stay (3.8 ± 2.3)d in the observation group were shorter than those in the control group (51.4 ± 6.1)h and (4.9 ± 3.7)d, and the incidence of complications was 3.79% low In the control group, the difference was statistically significant (15.18%) (P <0.05). The nursing satisfaction of patients in the observation group was 97.46% higher than that in the control group, which was 81.01%, and the difference was statistically significant (P <0.05)
Table 1 Comparison of extubation time, hospitalization time and complications between the two groups after nursing (n(%), x¯±s)
Group
Case
Complications
Extubation time(h)
hospitalization time (d)
observation group
79
3(3.79)*
38.3±4.7*
3.8±2.3*
Control group
79
12(15.18)
51.4±6.1
4.9±3.7
*P<0.05
Table 2 Comparison of nursing satisfaction between the two groups after nursing (n(%), %)
Group
Case
Satisfied
generally satisfied
dissatisfied
Nursing satisfaction
observation group
79
54(68.35)*
23(29.11)*
2(2.54)*
97.46*
Control group
79
42(53.16)
22(27.85)
15(18.99)
81.01
*P<0.05
Conclusion
The application of personalized nursing measures in thoracoscopic NSCLC surgery can shorten the intubation time of patients, improve the quality of nursing care, reduce complications such as retention of sputum, atelectasis and pneumonia, and also can effectively reduce the length of hospitalization of patients, which is worthy of clinical promotion.
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P14 - Immuno-biology and Novel Immunotherapeutics (Phase I and Translational) - Immuno-Biology (ID 153)
- Event: WCLC 2020
- Type: Posters
- Track: Immuno-biology and Novel Immunotherapeutics (Phase I and Translational)
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P14.10 - Efficacy of Anti-PD-1/PD-L1 Monoclonal Antibody Treatment of Advanced NSCLC on Density and Distribution of Tumor Infiltrating T Cells (ID 1877)
00:00 - 00:00 | Presenting Author(s): Yuanyong Wang
- Abstract
Introduction
To analyze the efficacy of anti-programmed death factor (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody in the treatment of advanced non-small cell lung cancer (NSCLC) and its effect on the density and distribution of tumor infiltrating T cells.
Methods
A total of 83 patients with advanced NSCLC treated in the Chinese PLA General Hospital from May 2015 to December 2015 were retrospectively divided into observation group (n = 42) and control group (n = 41). The control group was treated with docetaxel at a dose of 75 mg/m2, 3 per week. The observation group was treated with Nivolumab at a dose of 3 mg/kg, 2 per week. The clinical efficacy, the level of T lymphocyte subsets and the incidence of adverse reactions were compared between the two groups. COX regression model was established to analyze the factors affecting the survival of advanced NSCLC patients treated with PD-1/PD-L1 monoclonal antibody.
Results
There was no significant difference in the objective response rate (ORR) between the two groups, but the disease control rate (DCR) in the observation group was significantly higher than that in the control group (P < 0.05). After treatment, CD3+, CD3+/CD4+ and CD4+/CD8+ in the observation group increased significantly, while CD4+/CD25+ decreased significantly, and CD3+, CD3+/CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group, while CD4+/CD25+ was significantly lower than that in the control group. The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). The progression-free survival (PFS) of the observation group was 32.15%, and the overall survival (OS) was 47.83%, which was significantly higher than that of the control group (16.89%, 27.55%). Age ≥ 60 years old, third-line treatment, post-treatment CD3+/CD4+, post-treatment CD4+/CD25+ and adverse reactions were independent risk factors affecting the survival of NSCLC patients treated with anti-PD-1/PD-L1 monoclonal antibody, while smoking history and PD-1/PD-L1 treatment were protective factors.
Conclusion
Anti-PD-1/PDL1 monoclonal antibody has good efficacy and safety in the treatment of progressive NSCLC. It can effectively improve the immune status of patients and achieve better survival benefits. Age, smoking history, third-line treatment, CD3+/CD4+ and CD4+/CD25+ after treatment, and adverse reactions are independent factors affecting their survival.
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P32 - Palliative and Supportive Care - Misc. Topics (ID 220)
- Event: WCLC 2020
- Type: Posters
- Track: Palliative and Supportive Care
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P32.03 - Comparison of Two Nursing Effects in Patients With NSCLC Within 2 Hours After General Anesthesia (ID 1406)
00:00 - 00:00 | Presenting Author(s): Yuanyong Wang
- Abstract
Introduction
To discuss the effect of routine sleep and snoring warning within 2 hours after surgery on patients with NSCLC within 2 hours after general anesthesia.
Methods
After returning to the ward after operation, the 68 patients in the two groups were taken supine position, and were routinely given bedside ECG monitoring and nasal catheter oxygen 3 L/min inhalation. In the control group, within 2 hours after returning to the ward after general anesthesia, do not close patient’s eyes and sleep, and told the family members to have a continuous conversation with the patients within 2 hours to avoid falling asleep. The observation group fell asleep normally and asked the family members to accompany them at the bedside of the patient. When they found that the patients were snoring and breathing, they would wake up the patients. After the snoring disappears, the patient’s can go back to sleep. The incidence of SpO2 <90%, the degree of tiredness of patients and the comfort of family members were compared between the two groups.
Results
There was no significant difference in the number of SpO2 <90% in the two groups (P> 0.05). The sleepiness and family comfort of the experimental group were better than those of the control group (P <0.05).x¯
Comparison of the incidence of SpO2 < 90% between the two groups (n) Group Case SpO2 < 90% Without SpO2 < 90% P=0.555 observation group 34 1 33 Control group 34 2 31 Comparison of tiredness and family comfort between the two groups (degree, x¯±s) Group Case Patient fatigue degree Family members' comfort observation group 34 1.98±0.94 2.14±1.03 Control group 34 3.89±1.05 3.42±1.41 P <0.001* <0.001*
Conclusion
Routine sleep combined with snoring warning within 2 hours after operation does not increase the incidence of respiratory depression, but can improve the patient's sleepiness and family comfort.
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P65 - Tumor Biology and Systems Biology - Basic and Translational Science - NC RNA (ID 204)
- Event: WCLC 2020
- Type: Posters
- Track: Tumor Biology and Systems Biology - Basic and Translational Science
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P65.05 - Circular RNA circTBCD Promotes Lung Cancer Progression by Targeting Key miRNAs in Bioinformatics Analysis. (ID 3623)
00:00 - 00:00 | Author(s): Yuanyong Wang
- Abstract
Introduction
Lung cancer is the first leading cause of tumor- related deaths for both men and women in the whole world. Circular RNAs (circRNAs) represent a subclass of regulatory RNAs that have been shown to have significant regulatory roles in cancer progression. However, the biological functions of circRNAs in lung cancer are largely unknown.
Methods
Here we chose and verified the target circRNA TBCD(circTBCD) by bioinformatics. And then we knocked down the expression of the circTBCD by siRNA. We studied the proliferation and migration function of the circTBCD in vitro by EDU assay, MTT assay as well as wound healing assay. Then we predicted the potential target miRNA of circTBCD by circinteractome and circbank databases. Based on the miRNAs, we then obtained the probable target gene of miRNAs by miRDB and TargetScan databases. GO analysis and KEGG analysis on VAVID online tool demonstrated the potential function pathways of these genes.
Results
The circTBCD was overexpressed in lung adenocarcinoma in GSE101586. We have verified its character and its expression level in lung cancer cells and tissues. CircTBCD promoted the proliferation and migration in A549 and HCC2279 lung adenocarcinoma cells. The target miRNAs of circTBCD were hsa-miR-558, hsa-miR-604, hsa-miR-198, hsa-miR-635. The potential target genes of the miRNA were obtained by overlaying the miRDB and TargetScan database. The GO annotation and KEGG pathway analysis of these genes were performed utilizing the DAVID online tool. The significantly enriched entry for BPs was negative regulation of transcription, DNA-templated. Furthermore, cytoplasm and plasma membrane accounted for the majority of the CC terms. The most enriched MF was protein binding. What’s more, the genes mignt work by pathways in cancer and Ras signaling pathway.
Conclusion
These results revealed that circTBCD act as a tumor promotor in lung cancer, which have the important role in the proliferation, migration of lung adenocarcinoma cells potentially by pathways in cancer and Ras signaling pathway.
