Author of

• 35041

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  P09 - Health Services Research/Health Economics - Real World Outcomes (ID 121)

  • Event: WCLC 2020
  • Type: Posters
  • Track: Health Services Research/Health Economics
  • Presentations: 1
  • Moderators:
  • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall

  • 35072

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    P09.26 - Cause of Death in Patients with Squamous Cell Lung Cancer (SCC) Treated with Surgery (ID 2335)

    00:00 - 00:00  |  Presenting Author(s): Nirav Nicholas Antao
    • Abstract
    • Slides

    Introduction
    

    In patients with early stage squamous cell lung cancer (SCC), the standard of care treatment includes surgical resection followed by adjuvant chemotherapy (CT) in those with tumors greater than or equal to 4 cm or with lymph node involvement. Although large randomized studies report overall and relapse-free survival, there is limited data on the cause of death (COD), particularly within the first 12 months from diagnosis. The purpose of this study is to evaluate the survival and COD among patients with SCC treated with surgery.

    Methods
    

    The Surveillance, Epidemiology and End Report (SEER) was queried for patients with SCC stage I to IIIA according to AJCC 7^th edition, diagnosed between 1998 and 2016, treated with surgery with or without chemotherapy. Outcomes were subdivided into alive, death from lung cancer, death from another type of cancer, death from non-cancer causes and unknown.

    Results
    

    There were 26,530 patients (pts) that met the inclusion criteria, of which 16,757 (63.2%) died during the study period. The most common COD was lung cancer (9,046 pts, 54.0%), followed by death from other non-malignant causes (5,902 pts, 35.2%), and death from other cancers (1,721 pts, 10.3%). COD was unknown in 88 pts (0.5%). A total of 4,518 patients (17.0% of total pts and 26.9% of deaths) died within one year from diagnosis. Lung cancer was the most common COD within 12 months (2,869; 63.5%) followed by non-malignant causes (1,195; 26.4%), other malignancies (306; 6.7%) and unknown causes (24; 0.5%). The most common known causes of non-malignant deaths within one year were cardiovascular disease (422; 35.3%), chronic obstructive pulmonary disease (267; 22.3%), infection (160; 13.4%) and stroke (72; 6.2%).

    Conclusion
    

    In the general population represented by the SEER database, 17% of patients with early stage SCC undergoing surgery die within 12 months from diagnosis. Despite the indication for surgery and chemotherapy based on stage at diagnosis, better selection of patients according to co-morbidities and performance status may decrease the early mortality after treatment with curative intent.

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