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Satoshi Shiono
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P07 - Early Stage/Localized Disease - Imaging and Biomarkers (ID 116)
- Event: WCLC 2020
- Type: Posters
- Track: Early Stage/Localized Disease
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P07.01 - Less Accuracy of CT and PET in the Evaluation of N1 Node may Result in Overlooking Skip Metastasis of Single Station cN2 Non-Small Cell Lung Cancer (ID 3358)
00:00 - 00:00 | Presenting Author(s): Satoshi Shiono
- Abstract
Introduction
We have recently reported the surgical benefit for the clinical single station cN2 non-small cell lung cancer in the JTO Clinical Research Report. It has been demonstrated that the five-year overall survival rates for single station cN2 without and with N1 node enlargement were 81.3% and 37.5%, respectively. As a secondary endpoint, efficacy of preoperative computed tomography (CT) and 18F-fluorodioxyglucose positron emission tomography (PET) were studied.
Methods
For all 34 enrolled cases whose pathological N status was confirmed in the prospective phase II multicenter study (JNETS 0801), the accuracy, sensitivity and specificity of N2 and N1 nodes were investigated.
Results
The accuracy of CT for N2 node and N1 node were 76% and 62%, respectively, and that of PET for N2 node and N1 node were 89% and 61%, respectively. Especially for N2 node, the sensitivity and the specificity of PET were 100% and 40%, respectively. Besides, for N1 node, the sensitivity and the specificity of PET were 42% and 75%, respectively.
Conclusion
PET is demonstrated to be highly beneficial in the evaluation of N2 node status; however, it is less reliable for that of N1 node. Positive result of N1 node by combination of CT and PET may result in over diagnosis of the clinical N1 node metastasis, which could lead to overlooking skip metastasis and to the denial of surgical indication for potentially curative cN2 non-small cell lung cancer.
