Author of

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  P02 - Diagnostics and Interventional Pulmonology (ID 110)

  • Event: WCLC 2020
  • Type: Posters
  • Track: Diagnostics and Interventional Pulmonology
  • Presentations: 1
  • Moderators:
  • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall

  • 34881

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    P02.04 - Pectoral Muscle Area Correlates with LENT Score in Non-Small Cell Lung Cancer Associated Pleural Effusion Survival Prediction (ID 2403)

    00:00 - 00:00  |  Presenting Author(s): Austin Michael Meggyesy
    • Abstract
    • Slides

    Introduction
    

    The prognosis of patients who develop a malignant pleural effusion (MPE) is poor, with studies reporting a median survival of 6 months. The LENT prognostic score is the first validated stratification score to predict survival in MPE patients. It is established that cancer cachexia is associated with poor prognosis; in addition, recent studies have identified pectoral muscle area (PMA) to be a measure of sarcopenia and disease severity in pulmonary disease. We aimed to determine if PMA was associated with survival in patients with non-small cell lung cancer (NSCLC) and MPE.

    Methods
    

    We reviewed 152 NSCLC patients who underwent MPE management with a tunneled pleural catheter (TPC) between 01/01/2008-02/29/2020. Each patient’s PMA was recorded (by two independent researchers and averaged) from computed tomography performed within 45 days of TPC insertion. LENT score was calculated from the same time period. 78 patients were excluded: 44 for incomplete data, 20 for unknown death dates, 14 for scans/tests outside of 45 days of TPC insertion. Cox proportional-hazards regression analyses were performed.

    Results
    

    Median age at MPE diagnosis was 71 (interquartile range [IQR]: 64-79) years and 46% (34/74) were male. Median PMA was significantly higher in males (35cm², IQR: 27-41) compared to females (23cm², IQR: 19-27), p<0.001. Median PMA was significantly lower in patients with a ‘High Risk’ [24 cm² (IQR: 23-37)] LENT score classification than ‘Moderate Risk’ [31 cm² (IQR: 19-29)], p=0.005 (Figure). A higher PMA also correlated with better overall survival on univariate analysis (Table).

    

    Conclusion
    

    A lower PMA appears to be significantly associated with a ‘High Risk’ LENT score. This association could provide a basis for using PMA as a diagnostic tool to guide discussions related to survival and timing of palliative management. More research is needed to explore the relationships between PMA and severity of disease in patients with NSCLC and MPE.

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