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Mora Guardamagna



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    P38 - Pathology - Pathology/Staging (ID 108)

    • Event: WCLC 2020
    • Type: Posters
    • Track: Pathology, Molecular Pathology and Diagnostic Biomarkers
    • Presentations: 1
    • Moderators:
    • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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      P38.19 - Lung Cancer in Young Adults: A Two-Center, Retrospective Study of the Clinical and Pathological Characteristics (ID 3259)

      00:00 - 00:00  |  Presenting Author(s): Mora Guardamagna

      • Abstract
      • Slides

      Introduction

      Lung cancer is the main cause of death due to cancer worldwide, representing nearly 25% of the total deaths by cancer. It is mainly diagnosed in people around 70 years-old, counting just a few cases under 40. The objective of this study is to analize the characteristics of patients under 40 diagnosed of lung cancer, and describe the prognostic variables for a better understanding of this disease in this specific setting.

      Methods

      A retrospective, descriptive study of 47 patients between 15-40 years old diagnosed of lung cancer in Hospital Universitario Virgen de la Victoria and Regional Universitario de Málaga, from January 2000 to May 2020 was carried out. Family and personal background, histology, stage, and localization of the tumor was analyzed, as well as detection of molecular mutations and treatments given during the course of the disease. A frequency analysis of qualitative and quantitative variables was made. The survival curves were calculated by Kaplan Meier, with a level of significance of p<0,05.

      Results

      Median age was 34 years-old (range 15-40), of which 51% were women (n=24), without previous oncological family history in a 76,6% (n=36), and smoking history in a 55% (n=18). Diagnostic symptoms were mainly pain (28,2%), cough (17,9%) and dyspnea (10,3%), and regarding histology, 38% were adenocarcinomas and 21,3% typical carcinoids. As reported in previous studies, around 79% (n=36) were advanced stages, TNM III-IV. Mutation-gene analysis was made in 40% (n=19) of the patients, 12,7% being positive for EGFR (n=6) and 4,3% for ALK (n=2), all of which where treated with genotype-directed treatment.

      Median-overall survival was 102 months (range 22-182), being just 17 months in the subgroup of non-carcinoid tumors, with a progression-free survival of 6 months.

      Conclusion

      Lung cancer in young adults is a non-frequent pathology that represents an interesting challenge for the Oncologist. Recognizing physiological and molecular characteristics will enable a better clinical and therapeutic approach.

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