Author of

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  P36 - Pathology - Prognosis (ID 106)

  • Event: WCLC 2020
  • Type: Posters
  • Track: Pathology, Molecular Pathology and Diagnostic Biomarkers
  • Presentations: 1
  • Moderators:
  • Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall

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    P36.10 - Prognostic Value and Transcriptional Expression Profile of GINS Family Members in Lung Adenocarcinoma (ID 2907)

    00:00 - 00:00  |  Presenting Author(s): Fangyan Zhong
    • Abstract
    • Slides

    Introduction
    

    Lung adenocarcinoma (LUAD) is one of the common pathological types in lung cancer. Although many oncogenic drivers have been found and new therapies are emerging, patients who are diagnosed with LUAD still have a poor 5-years overall survival rate. It is imperative that we should try our utmost to discover novel molecular targets. Among them, GINS complex was found to be a core components of replication helicases in eukaryotes, and its abnormal function may lead to the cause of malignant neoplasms and other diseases. Although many studies have shown an association between members of the GINS family (GINSs) and lung cancer, few attempts have been made to find an association between GINSs and the pathological type LUAD.

    Methods
    

    In this study, ONCOMINE database, UALCAN and Human Protein Atlas were used to investigate the role of GINSs in the transcription expression profiles of LUAD patients.KM-plotter and DriverDBv3 database were employed to analyze the correlation between gene expression of the GINSs and clinical prognosis. Finally, by utilizing LinkedOmics database, we screened GINSs-related differentially expressed genes and performed GO, KEGG analysis on these genes

    Results
    

    We found that all GINS genes are highly expressed in LUAD and are associated with poor survival of LUAD patients, especially those who had smoking history.mRNA expression of all four GINSs have statistically significant difference between tumor samples and normal samples (p<0.001). Patients tended to express higher mRNA in more advanced stages and the highest mRNA expression of GINSs are all observed in stage IV.Additionally, we found that co-overexpression of two or more GINSs was associated with poor prognosis, suggesting the GINSs complex may co-operate to promote LUAD progression. KEGG pathway analysis showed that these overlapped genes activate these pathways of cell cycle, spliceosome, RNA transport, purine metabolism ribosome and Parkinson disease.We had also obtained some GINSs-related kinase targets and transcription factor targets, which may serve as a future research direction.

    Conclusion
    

    We propose that individual GINSs or combinations of multiple GINS genes may be potential biomarkers for the prognosis of patients with LUAD.

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