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Linda Coate
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ES05 - Value in Lung Cancer, from Screening to Treatment (ID 203)
- Event: WCLC 2020
- Type: Educational Session
- Track: Health Services Research/Health Economics
- Presentations: 1
- Moderators:
- Coordinates: 1/29/2021, 14:15 - 15:15, Scientific Program Auditorium
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ES05.05 - Age, Gender and Ethnicity: Disparities in Lung Cancer (ID 4041)
14:15 - 15:15 | Presenting Author(s): Linda Coate
- Abstract
- Presentation
Abstract not provided
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P76 - Targeted Therapy - Clinically Focused - EGFR (ID 253)
- Event: WCLC 2020
- Type: Posters
- Track: Targeted Therapy - Clinically Focused
- Presentations: 1
- Moderators:
- Coordinates: 1/28/2021, 00:00 - 00:00, ePoster Hall
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P76.49 - The Impact of Baseline Systemic Inflammatory Status Parameters in Patients Treated with EGFR-Tyrosine Kinase Inhibitors (ID 2272)
00:00 - 00:00 | Author(s): Linda Coate
- Abstract
Introduction
Elevated neutrophil to lymphocyte ratio (NLR),derived neutrophil to lymphocyte ratio (dNLR),lung immune prognostic index (LIPI) and circulating tumour cells (CTCs) are associated with inferior outcomes in non-small cell lung cancer (NSCLC). The use of these parameters in patients treated with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is uncertain. We assessed the association of pre-treatment NLR, LIPI and CTCs on time to progression (TTP) and overall survival (OS) in patients treated with EGFR-TKIs.
Methods
Patients with existing EGFR-activating mutations on EGFR TKIs (cohort 1) and newly diagnosed, treatment naive (cohort 2) were recruited across three Irish Oncology centres over a two year period (n=21). Demographic characteristics were collected. Baseline NLR, dNLR (absolute neutrophil count/white blood cell concentration-absolute neutrophil count), LIPI (dNLR greater than 3 and LDH greater than ULN) consisted of 3 groups (good: 0 factors; intermediate: 1 factor; poor: 2 factors), and CTCs count was collected at baseline. CTCs were isolated from blood using ScreenCellÒ size exclusion technology.Cox proportional hazards analysis was used for overall survival (OS) and time to progression (TTP). Correlations were performed using the Wilcoxon sign rank test.
Results
16 (76%) of patients were female (median age 64.5), 20 (95%) were adenocarcinoma, 1 (5%) squamous cell carcinoma, 10 (48%) never smokers, 10(48%) ex-smokers.There was a significant correlation between LDH (p=0.02), CTCs (p=0.00067) and WCC in cohort 1. CTC count was also significantly correlated with LDH (p=0.001) in cohort 1. There was a significant correlation between LDH (p=0.003), NLR (p=0.0005) and WCC in cohort 2. NLR was also significantly associated with LDH (p<0.05). There was no significant correlation between dNLR and CTCs in either cohort. WCC, LDH, dNLR, CTCs and LIPI were not significantly associated with TTP and OS in either cohort.
Conclusion
Although there were positive correlations between baseline systemic inflammatory parameters, these were not prognostic for survival in patients treated with EGFR-TKI therapy. Larger clinical studies and sequential follow up parameter measurements during treatment will be valuable in assessing these markers during EGFR-TKI therapy.
