Author of

• 32838

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  P1 - Poster Viewing (ID 5)

  • Event: NACLC 2019
  • Type: Poster Session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/11/2019, 16:45 - 18:00, Exhibit Hall

  • 33397

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    P1.08 - Immunophenotyping of CD 146 Expression T Cells in Lung Cancer Patients (ID 31)

    16:45 - 18:00  |  Author(s): Xiaoju Zhang
    • Abstract

    Background:
    Immunophenotyping of CD 146 is the exploration of heterogeneous populations of CD 146 in the T cells for identifying the presence, expression, and proportions
    
    
    Method:
    Blood was collected from lung cancer patients and from healthy subjects. Flow cytometry was used for the determination of CD146+ utilizing CD 4+, CD 25+ , CD 127 dim/-. Granulocytes, monocytes and lymphocytes apoptosis were determined by 7-amino-actinomycin D/Annexin V-APC staining during the resting stage and after 24hours.
    
    
    Results:
    The expression of CD 146+ was significantly higher in patients than in controls (P< 0.05). From the flow cytometry, the expression of the CD 146+ in the T cells includes 4.60 % in healthy patients, 10.10 %, 12.20 %, 9.80 % in adenocarcinoma, squamous and small cell lung cancer respectively.
    
    
    Conclusion:
    Increased in the percentage of the expression of CD 146+ in the T cells of the adenocarcinoma, squamous and small cell lung cancer patients unveil the clinical importance of CD 146+, which is a potential biomarker. To better comprehend and exploit Treg-cell biology in association with carcinogenesis and tumorigenesis, it will be very interesting to investigate more specific cell-surface markers.