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Murat Kapdağlı



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    P2.13 - Staging (ID 315)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Staging
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.13-11 - Predicting Micrometastasis in Mediastinal Lymph Nodes in Patients with Non-Small Cell Lung Cancer (Now Available) (ID 1945)

      10:15 - 18:15  |  Author(s): Murat Kapdağlı

      • Abstract
      • Slides

      Background

      Non-small-cell lung cancer staging is the most important factor affecting both the potential treatment and the prognosis. The evaluation of non-small cell lung carcinoma staging uses the TNM classification (tumor, node, metastasis). The N factor plays a more critical role in staging than T and M factors, because of its unpredictability. We know that undiagnosed micrometastatic nodal disease has a poor prognosis. Detecting micrometastasis is expensive and time consuming, so that’s why we aimed to investigate the factors predicting micrometastatic mediastinal disease.

      Method

      We collected all the lymph nodes from the patients that we operated between July 2012 and July 2013. We excluded all the patients who had an induction treatment and preoperatively diagnosed with mediastinal metastasis. We studied the expressions of three biomarkers; EpCAM, CEACAM5 and KRT19 using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in lymph nodes and compared the expressions with healthy controls. If all three of them are positive, we have accepted it as micrometastasis. We compared the presence of micrometastasis with the pathological data to identify possible predictive factors.

      Result

      We analyzed 86 lymph nodes from 32 patients. Twenty seven out of 86 lymph nodes (%31.4) were positive for micrometastasis. Eighteen out of 32 patients (%56.3) became micrometastatic and 16 out of 32 patients are upstaged. Four of them are upstaged from N1 to N2 and 12 of them are upstaged from N0 to N2. Micrometastatic patients tend to have poorer survival compared to non-micrometastatic patients but without an statistical significance. However micrometastasis was found significantly higher in tumors with less than 2 cm (p: 0.03) and lower in tumors without lymphovasculary invasion (p: 0.03).

      Conclusion

      In our study tumors with smaller than 2cm in diameter and without lymphovascular invasion have significantly higher micrometastatic potential. In order to validate these parameters as predictive markers this experiment should be performed in a larger cohort with increased control population.

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