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Pedro Henrique Cunha Leite



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    P2.13 - Staging (ID 315)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Staging
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.13-09 - The Impact of the 8th Edition of IASLC Staging in Patients Who Underwent Surgical Treatment of Lung Cancer (Now Available) (ID 2329)

      10:15 - 18:15  |  Author(s): Pedro Henrique Cunha Leite

      • Abstract
      • Slides

      Background

      TNM cancer staging main function is to unify the language of patient´s evaluation. It is supposed to be a global initiative, however participation of latin american patients in the IASLC database is limited and the performance of staging in such a population is unknown.Our study aims to describe the performance of TNM 7th and 8th editions in predicting survival of patients with lung cancer who underwent surgical treatment in a latin american country.

      Method

      This is a retrospective study conducted in a Oncologic hospital of São Paulo, Brazil. We selected the patients who underwent surgical treatment of lung cancer between January 2011 and December 2015. Clinical data was obtained from the institutional database including exactly the same variables as the IASLC database. Patients were classified according to the TNM clinical and pathological staging system, both in 7th and 8th editions. Then we performed a survival analysis in 36 months according to each classification using the Kaplan–Meier method. A Cox regression was made with the clinical and pathological staging as variables, in order to determine which classification was more precise in risk prediction.

      Result

      The mean age was 63,9 (±11.6), female predominance (53%), and strong association with current or former smoking (74%). The most common histological type was invasive adenocarcinoma (54%) followed by squamous cell carcinoma (22%). Both TNM classifications stratified risk adequately as demonstrated in Image 1.

      curvas iaslc abstract.jpg

      According to the Cox regression, TNM 8th edition had a better performance in survival prediction.

      Clinical 7th ed (LL=-329.14095; LR=6.29) versus Clinical 8th ed (LL=-25.91923; LR=12.73). Pathological 7th ed (LL=-318.82608; LR=26.92) versus Pathological 8th ed (LL=-315.19067; LR=34.19).

      Conclusion

      TNM 7th and 8th editions predicted adequately survival in patients of a Latin American country, suggesting that these classifications are generalizable for such a population. 8th edition had a better performance when compared to 7th edition.

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