Author of

• 32243

  +

  EP1.16 - Treatment in the Real World - Support, Survivorship, Systems Research (ID 206)

  • Event: WCLC 2019
  • Type: E-Poster Viewing in the Exhibit Hall
  • Track: Treatment in the Real World - Support, Survivorship, Systems Research
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall

  • 32258

    +

    EP1.16-15 - Subclinical Interstitial Lung Disease Is a Risk Factor for Radiation Pneumonitis in Patients with Lung Cancer After Thoracic Radiation Therapy (ID 1512)

    08:00 - 18:00  |  Author(s): Hongyu Wu
    • Abstract

    Background
    

    Previous studies reported that patients with subclinical interstitial lung disease were more susceptible to developing radiation pneumonitis after thoracic stereotactic body radiotherapy or thoracic 3-dimensional conformal radiotherapy . The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with lung cancer with or without preexisting subclinical interstitial pulmonary disease.

    Method
    

    Patients with lung cancer between May 2016 and August 2018, who were treated with thoracic intensity-modulated radiation therapy in our institutions, were prospectively analyzed. Statistical analysis was performed using SPSS software 22.0 for Mac. Univariate and multivariate analyses were used to assess the correlation of subclinical interstitial lung disease with radiation pneumonitis and risk factors of radiation pneumonitis. A P value < 0.05 was considered statistically significant.

    Result
    

    A total of 123 patients with lung cancer were prospectively analyzed. The median follow-up time was 13.9 months. Radiation pneumonitis was observed in 30, 18, 2 and 1 patient with grades 1, 2, 3 and 5 radiation pneumonits, respectively. No patient suffered from ≥grade 4 radiation pneumonitis. The incidence of ≥grade 2 radiation pneumonitis was 17.1%. Mean lung dose, V10, V20, V30 and subclinical interstitial lung disease before radiotherapy were associated with an increased incidence of ≥grade 2 radiation pneumonits in univariate analysis. Subclinical interstitial lung disease and mean lung dose were significantly associated with ≥grade 2 radiation pneumonits in multivariate analysis (P=0.022, P=0.018, respectively).

    Conclusion
    

    Preexisting subclinical interstitial lung disease and mean lung dose are predictors of ≥grade 2 radiation pneumonits.