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Iveta Kuliskova



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    EP1.14 - Targeted Therapy (ID 204)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Targeted Therapy
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.14-34 - Advanced NSCLC Treated with Gefitinib or Erlotinib for Five Years or Longer - Updated Data from the Retrospective Slovakian Study (Now Available) (ID 3009)

      08:00 - 18:00  |  Author(s): Iveta Kuliskova

      • Abstract
      • Slides

      Background

      Median PFS in the key phase III trials with gefitinib or erlotinib for advanced NSCLC with EGFR sensitizing mutations was less than 12 months. There are only a few data about the treatment results and toxicity of long-term treatment lasting 5 years or over. Purpose of this study was to find patients treated with either gefitinib or erlotinib for at least 5 years and to evaluate the treatment results in this group of patients.

      Method

      Retrospective multicentre study, approved by the Ethics Committee of the Specialised Hospital of St Zoerardus Zobor, Nitra. All thoracic oncology centres in Slovakia were involved. For this update also the other hospitals and oncology outpatient departments were asked to participate. Data regarding patients were obtained from the databases of participating institutions and patient files. Descriptive statistics was used for the data analysis.

      Result

      At the IASLC WCLC 2018 we presented data about seven patients included in the study. Here we present the data about another two patients, and updated data about the previously found seven patients. Characteristics of patients and the treatment results are summarised in the Table. Median PFS in this exceptional group was not reached, but it will be over 80 months. There was only one patient with the decreased dose of erlotinib (from 150 to 100 mg QD) due to skin toxicities. All the other patients had the common and manageable grade I – II toxicities only, and there were no unexpected drug-related AEs.

      Table: Patients characteristics and treatment results

      Gender
      (M/W)
      Age
      (yrs)
      Smoking
      status
      PS Histology,
      Cytology
      NSCLC
      stage
      EGFR
      mutation
      Treatment line/TKI Response PFS
      (mo)
      W 72 Ex 2 AC IV Del 19* 1st/gefitinib SD 67
      W 53 Smoker 1 AC IV NK 1st/erlotinib SD 112+
      W 58 Never 1 AC/SQ IIIB NK 2nd/erlotinib PR 94+
      W 69 Never 1 AC IV NK 2nd erlotinib SD 87+
      W 72 Never 1 AC IV Del 19 2nd erlotinib PR 75+
      W 59 Never 1 AC IV L858R 1st/erlotinib PR 72
      M 64 Never 1 AC/SQ IV NK 2nd/erlotinib PR 108+
      M 70 Ex 1 SQ IV NK 2nd/erlotinib SD 102+
      W 50 Never 1 AC IV Del 19 1st/gefitinib PR 66

      *Del 19 and T790M

      Conclusion

      The treatment was safe and effective in our group of patients with advanced NSCLC treated with gefitinib or erlotinib for over 5 years. The NGS analysis of the available samples will be done after approval of the submitted Protocol by the Ethics Committee.

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