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Ozgur Ekinci



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    EP1.14 - Targeted Therapy (ID 204)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Targeted Therapy
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.14-22 - Amplification and Overexpression of MET in Brain Metastases of Non‐Small Cell Lung Cancer (Now Available) (ID 2656)

      08:00 - 18:00  |  Author(s): Ozgur Ekinci

      • Abstract
      • Slides

      Background

      Non-small-cell lung carcinoma (NSCLC) with MET amplification may respond to c-MET inhibitors.

      Method

      We investigated MET gene amplification status by fluorescence in-situ hybridization (FISH) and c-MET protein expression by immunohistochemistry of 42 NSCLC brain metastases (34 adenocarcinoma, 4 squamous cell carcinoma, 4 NSCLC-NOS).

      Result

      We found MET gene amplification in 7/42 (21.6%) and c-MET protein expression in 9/42 (21%) of evaluable brain metastasis. There was no correlation between the presence of MET gene amplification and c-MET protein expression (p<0.1, Chi square test). One patient with MET amplification also had EGFR mutation. Three patients with c-Met overexpression had ALK rearrangement.

      Conclusion

      c-MET overexpression and MET amplification are commonly found in brain metastasis of NSCLC and may represent a promising therapeutic target.

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