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Ozgur Ekinci
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EP1.14 - Targeted Therapy (ID 204)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Targeted Therapy
- Presentations: 1
- Now Available
- Moderators:
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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EP1.14-22 - Amplification and Overexpression of MET in Brain Metastases of Non‐Small Cell Lung Cancer (Now Available) (ID 2656)
08:00 - 18:00 | Author(s): Ozgur Ekinci
- Abstract
Background
Non-small-cell lung carcinoma (NSCLC) with MET amplification may respond to c-MET inhibitors.
Method
We investigated MET gene amplification status by fluorescence in-situ hybridization (FISH) and c-MET protein expression by immunohistochemistry of 42 NSCLC brain metastases (34 adenocarcinoma, 4 squamous cell carcinoma, 4 NSCLC-NOS).
Result
We found MET gene amplification in 7/42 (21.6%) and c-MET protein expression in 9/42 (21%) of evaluable brain metastasis. There was no correlation between the presence of MET gene amplification and c-MET protein expression (p<0.1, Chi square test). One patient with MET amplification also had EGFR mutation. Three patients with c-Met overexpression had ALK rearrangement.
Conclusion
c-MET overexpression and MET amplification are commonly found in brain metastasis of NSCLC and may represent a promising therapeutic target.