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Shouzheng Wang
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EP1.14 - Targeted Therapy (ID 204)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Targeted Therapy
- Presentations: 1
- Now Available
- Moderators:
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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EP1.14-19 - Efficacy and Safety of Afatinib for Advanced Lung Adenocarcinoma Patients with Sensitive EGFR Mutations in Chinese Population (Now Available) (ID 817)
08:00 - 18:00 | Presenting Author(s): Shouzheng Wang
- Abstract
Background
Afatinib is an irreversible ErbB family blocker that improves progression-free survival (PFS) of advanced EGFR-mutant lung adenocarcinoma, comparing with chemotherapy. However, afatinib leads to more adverse events than first-generation EGFR inhibitors. Hence, exploration of optimal afatinib initial dose and its efficacy and safety for Asian patients has drawn extensive attention.
Method
We retrospectively investigated advanced NSCLC patients treated with afatinib from February 27, 2017 to October 30, 2018. Demographic and clinical information, survival data and adverse events were collected and evaluated.
Result
A total of 60 patients were included into this study. Thirty-nine (65%) patients received afatinib as first-line treatment. Median PFS for first-line afatinib treatment was 15.64 months [95% confidence internal (CI), not reached] and median OS has not been reached. When including age, sex, smoking history, baseline brain metastasis status, afatinib starting dose and mutation types into a multivariate COX regression analysis, PFS of patients with common sensitive EGFR mutations only was significantly longer than that of patients with uncommon mutations [hazard ratio (HR), 0.256; 95%CI, 0.080-0.823; p=0.022]. No significant difference was observed in median PFS between patients treated with a starting dose of 40mg and 30mg (11.18 vs. 5.25 months, p=0.060). The incidence of all grades rash/acne (92.5% vs. 61.1%, p=0.011) and paronychia (82.5% vs. 50.0%, p=0.010) of 40mg group was significantly higher than that of 30mg group.
ConclusionTable 1. Afatinib-Related Adverse Events
Adverse events
All Patients
Afatinib 40mg
Afatinib 30mg
N=58
N=40
N=18
N
%
N
%
N
%
p
Diarrhea
50
86.2
36
90.0
14
77.8
0.402
≥Grade 3
6
10.3
5
12.5
1
5.6
0.736
Rash/acne
48
82.8
37
92.5
11
61.1
0.011
≥Grade 3
2
3.4
2
5.0
0
0.0
1.000
Paronychia
42
72.4
33
82.5
9
50.0
0.010
≥Grade 3
2
3.4
2
5.0
0
0.0
1.000
Stomatitis/mucositis
41
70.7
29
72.5
12
66.7
0.652
≥Grade 3
0
0.0
0
0.0
0
0.0
-
Dry skin
22
37.9
16
40.0
6
33.3
0.628
≥Grade 3
0
0.0
0
0.0
0
0.0
-
Pruritus
9
15.5
7
17.5
2
11.1
0.818
≥Grade 3
0
0.0
0
0.0
0
0.0
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First-line afatinib treatment is beneficial to advanced lung adenocarcinoma with sensitive EGFR mutations. Initial dose and baseline brain metastasis status do not impact PFS significantly.