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Yamato Motooka



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    EP1.12 - Small Cell Lung Cancer/NET (ID 202)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Small Cell Lung Cancer/NET
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.12-03 - The Significance of INSM1 Expression in Small Cell Lung Cancer (Now Available) (ID 2132)

      08:00 - 18:00  |  Author(s): Yamato Motooka

      • Abstract
      • Slides

      Background

      We previously demonstrated that INSM1 expressed in NE tumors (NETs) exclusively and INSM1 is a highly sensitive and specific immunohistochemical (IHC) marker in NETs, such as small cell lung cancer (SCLC). In the present study, we investigated 1) diagnostic performance of INSM1 in the diagnosis of SCLC in various types of samples 2) the association of INSM1 with clinical course.

      Method

      We evaluated INSM1 as an IHC marker in 384 formalin-fixed paraffin-embedded lung cancer samples (291 surgically resected samples (90 SCLCs and 201 NSCLCs) and 55 CT-guided biopsy samples (25 SCLCs and 30 NSCLCs)), in 50 cytology samples (25 SCLC metastatic lymph nodes and 25 NSCLCs) obtained by endobronchial ultrasound-guided transbronchial needle aspiration. The mRNA expression levels of INSM1 was examined using qRT-PCR in 37 SCLCs and 40 NSCLCs. We evaluated the association of INSM1 expression (IHC and qRT-PCR data) with clinical course.

      Result

      INSM1 was expressed in 94% of formalin-fixed paraffin-embedded SCLC samples (109/115) and in 92% of cytology SCLC samples (23/25). Whereas, 4 out of 231 formalin-fixed paraffin-embedded NSCLC cases (1.7%) had weak expression of INSM1 and none of the cytology NSCLC samples were positive. The mRNA level of INSM1 was significantly higher in SCLCs including in two cases who were INSM1 negative with IHC. No association between IHC positivity and mRNA expression level of INSM1 with evaluated clinical features including overall survival was observed.

      Conclusion

      Our study suggests INSM1 is a reliable IHC marker for SCLC in various types of clinical samples. There was no association between INSM1 and clinical courses in the present study.

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