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Franscisco Mascarenhas



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    EP1.11 - Screening and Early Detection (ID 201)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Screening and Early Detection
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.11-18 - Follow-up and Recurrence After Surgery in Patients with Non-Small-Cell Lung Cancer (Now Available) (ID 1998)

      08:00 - 18:00  |  Author(s): Franscisco Mascarenhas

      • Abstract
      • Slides

      Background

      Lung cancer is one of most common cause of cancer death in the world. Surgery is a potentially curative intervention in early stages of non-small-cell lung cancer (NSCLC), although some patients develop recurrence. Identification of factors related to recurrence is essential to reduce it.

      Method

      The objectives of this study were to evaluate the follow-up of patients with early stage NSCLC who undergoing surgical resection, as well as, the factors related to recurrence.

      We retrospectively evaluated patients with early-stage NSCLC (stage 0-II) who underwent surgical resections between January 2015 and December 2017 at Hospital da Luz – Lisboa. Patients were evaluated at a multidisciplinary lung cancer tumour board team meeting and followed according to international guidelines. We characterised demographic, clinical and radiological features, surgical procedure, histology and follow-up. The mean and standard deviation were shown; the T-student and Fisher tests were used; P value ≤0.05 was considered significant.

      Result

      There were included 46 resected NSCLC: 41 (89.1%) adenocarcinoma (ADC) – 25 invasive ADC, 11 ADC in situ (Tis) and 5 minimally invasive ADC; 4 (8.7%) epidermoid and 1 (4.2%) pleomorphic carcinoma. Twenty-seven (58.7%) were female and 29(63.0%) were current or former smokers; mean age was 63.1±9.3 years old (37-82).

      We underwent 30 (65.2%) lobectomies, 13 (28.3%) anatomic segmentectomies, 2 (4.3%) wedge resections and 1 (2.2%) bilobectomy, all with mediastinal lymph node dissection. No major complications were reported.

      Regarding surgical stage, 11 (23.9%) were stage 0, 26 (56.5%) Ia, 7 (15.2%) Ib, and 2 (4.3%) IIa.

      Thirty-nine (84.8%) patients were in follow-up or died due to non-lung cancer cause (1 case). The follow-up was 28.7±8.5 (12-47) months. Recurrence was documented in 4 (8.7%) patients; the time of recurrence development was 14.8±9.2 (4-26) months; Second primary lung cancer occurred in 3 6.5%) patients.

      Comparing recurrence and follow-up groups, there was only difference regarding age (73.0±7.8 vs 62.4±9.1; p=0.032) - gender (p=1.0), smoking history (p=0.621), nodule characteristics (solid vs sub solid) (p=0.140), lung resection (lobar vs sublobar) (p=0.297) and stage (stage 0/I vs stage II) (p=1.0). All Tis lesions were in follow-up.

      Conclusion

      In this group with resected early-stage NSCLC, most of the patients were in follow-up and the age was the only factor associated to NSCLC recurrence. Although low recurrence documented, it is essential to perform more accurate patient selection ensuring a radical cure. Probably other variables, as molecular/genetic parameters, can help to identify those with high-risk recurrence and the liquid biopsy can be useful in the detection of lung cancer recurrence.

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