Author of

• 32067

  +

  EP1.11 - Screening and Early Detection (ID 201)

  • Event: WCLC 2019
  • Type: E-Poster Viewing in the Exhibit Hall
  • Track: Screening and Early Detection
  • Presentations: 1
  • Now Available
  • Moderators:
  • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall

  • 32079

    +

    EP1.11-11 - Familial Lung Cancer: A Call for Action (Now Available) (ID 1843)

    08:00 - 18:00  |  Author(s): Rosa Madureira
    • Abstract
    • Slides

    Background
    

    Lung cancer (LC) is the most deadly of all cancers mostly due to the fact that the disease is often detected at an advanced stage with less effective treatment options. While 80% of lung cancers can be directly attributable to tobacco smoking, the disease has been increasing in non smokers raising awareness to other risk factors that could be screened for and controlled in order to achieve higher rates of early stage diagnosis.

    Method
    

    A retrospective analysis of the electronic records of LC patients followed in our district hospital between May 2012 and December 2018 was conducted. Patients with family history of cancer were selected and their demographic characteristics, smoking status, co morbidities and LC characteristics were analyzed.

    Result
    

    A total of 524 patients were followed, 33 of whom with a positive family history of cancer (20 men and 13 women, median age of 61.7years old at diagnosis +- 12.8 years). Only 9 were never smokers and 63.6% (21) were diagnosed following the investigation of symptoms. The majority (24) had an adenocarcinoma subtype (3 EGFR mutations, 1 ALK translocation and 2 HER2 amplification were identified).

    Twenty patients (60.6%) had a family history of LC and the most frequent family member affected were parents (father: 14; mother: 11) and siblings (11). Cancer affected at least 2 family members of 15 patients. At the time of diagnosis 19 of the 20 patients with LC family history had an ECOG Performance Status of 0-1 and 8 (40%) had advanced stage disease.

    We found no significant difference in stage at diagnosis, smoking status or symptoms at diagnosis between patients with and without a LC family history of malignancy (p=0,120, p=0,117 and p=0,814 respectively).

    Conclusion
    

    Studies demonstrating evidence of familiar aggregation of LC suggest a possible genetic susceptibility to this malignancy. Identification of individuals at particularly high risk of lung cancer due to this type of susceptibility would contribute to early detection and possibly to prevention through targeted and intense anti-smoking efforts. Perhaps due to the small dimension of our study population, our patients were not diagnosed in early stages of the disease despite a positive family history of lung cancer. This raises the question whether this particular group of people should be selected for specific cancer screening to allow for the possibility of curative treatments.

    Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.