Virtual Library

Start Your Search

Beti Zafirova



Author of

  • +

    EP1.10 - Prevention and Tobacco Control (ID 200)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Prevention and Tobacco Control
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
    • +

      EP1.10-02 - Risk for Occurrence of Lung Cancer Among Exposed to Professional Agents: A Case-Control Study (ID 1460)

      08:00 - 18:00  |  Author(s): Beti Zafirova

      • Abstract

      Background

      Lung cancer (LC) is the most frequent disease worldwide, but, with great differences among different regions. About 5% of the lethal cases, caused by cancer, are determined by the exposure to some substances, present at the working place. The most important cancerogenes for occurrence of professional cancer are ionizing radiation and various chemical and physical agents. For purposes of this study was used classification of the professional cancerogenes according to the International Agency for Research on Cancer (IARC). The exposure to carginogenes from group I (established) and 2A (probable) is taken into account.The aim of this investigation is to observe the eventual causal accociations among the professional exposure and the occurence and distribution of the lung cancer.

      Method

      This was a case-control study. It comprised 185 patients with LC and matched controls with no malignant diseases. By calculating the odds-ratios, the risk factors that play a role in the disease onset, have been estimated. Statistical significance of the examined variables as risk factors has been defined with confidence intervals.

      Result

      Professional exposure was present in 127 (68,6%), individuals with LC. Most of them were exposed on established (77,2%), and the others (22,8%) on probable cancer agents.The greatest part from the exposed was with more than 20 years at the same working place (established-72,4%;probable-69%). In the diseased group there was total of 124 actual smokers. Out of them, professionally exposed were 89 (71,8). Exposed to established cancer agents had 1,12% (95%CI, 0,70<OR<1,75), times greater risk to become ill from LC, compared to the non-exposed ones. Various are professions in individuals with LC. Greater frequency of the disease was registered in: constructors (present in 18,9% from the total exposed of the professional cancer agents), farmers (17,3%), transport workers (drivers, tractor drivers) (15,0%), mechanicals (8,7%).The most exposed were the farmers, in whom the average timeduration of the exposure was 36,36±9,04 years. The greatest part of the diseased farmers, transport workers and mechanicians had more than 30-year period of working. Transport workers had 2,50 (95%CI, 1,01<OR<6,15), while the mechanicians had 2,31 (95%CI, 0,76<OR<7,07), times non-significantly greater risk to become ill from LC in relation to non-exposed individuals.

      Conclusion

      In order to the determined role of some professional cancer agents in occurrence of LC, prevention of this disease means several activities, among which are:complete elimination of the agents present at the working place, decrease of its concentration as well as the decrease of the exposition to the agent.