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Liying Chen



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    EP1.04 - Immuno-oncology (ID 194)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Immuno-oncology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.04-16 - Predictive Markers for Efficacy in Malignancies Treated with Immune Checkpoint Inhibitors (Now Available) (ID 2171)

      08:00 - 18:00  |  Author(s): Liying Chen

      • Abstract
      • Slides

      Background

      Predictive markers for tumor response and efficacy of immune checkpoint inhibitors (ICIs) are still controversial. Measurements of the widespread biomarkers, such as PD-L1 expression or tumor mutational burden, are invasive and costly. Therefore, we investigated several accessible factors to predict prognosis.

      Method

      Clinicopathologic features and previous treatment records were collected from 64 patients with diverse malignancies between 2016 and 2018 in oncology department of Xinqiao hospital. Endpoints were progression free survival (PFS) and best overall response (bOR). The best cut-off points of continuous variables were determined by R. Kaplan-Meier was applied to analyze survival. The correlations between bOR and biomarkers were analyzed by Chi-square test.

      Result

      After a median follow-up of 5.5 months, a significant improvement in PFS was observed in 38 patients with higher body mass index (BMI, cut-off=21.45kg/m2) compared to the other 26 patients (10.0 months vs 4.6 months, p=0.015), also the former experienced a tendency of higher bOR rate (28.9% vs 11.5%, p=0.178). Moreover, patients who had radiotherapy records experienced better PFS (12.3 months vs 4.5 months, p=0.019) and higher bOR rate (26.1% vs 19.5%, p=0.542) than the others. Further, receiving antibiotics during immunotherapy was a negative factor in the prognosis of ICIs, which led to worse PFS (4.2 months vs 9.7 months, p=0.019) and lower bOR rate (8.3% vs 25.0%, p=0.383) than its counterparts.wclc.jpg

      Conclusion

      Higher BMI and radiotherapy records are associated with better clinical outcomes of immunotherapy, while receiving antibiotics is negatively correlated with efficacy of ICIs.

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