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Osamu Araki



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    EP1.04 - Immuno-oncology (ID 194)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Immuno-oncology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.04-14 - Effects of FoxP3-Positive Regulatory T Cell on Lymphoid Follicle Formation of Patient with Lung Squamous Cell Carcinoma (Now Available) (ID 863)

      08:00 - 18:00  |  Author(s): Osamu Araki

      • Abstract
      • Slides

      Background

      We have reported that lymphoid follicle formation by tumor infiltrating lymphocytes (TILs) is a negative predictor of patients with lung squamous cell carcinoma (SCC) following surgery. However, the role of FoxP3-positive regulatory T cells on lymphoid follicle formation and survival is still unclear

      Method

      Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and immunohistochemistry of TILs.

      Result

      Appearance of CD3/25/FoxP3-triple positive regulatory T cell was correlated with lymphoid follicle formation (p=0.001). Univariate analysis showed that pathological stage (p=0.037), lymphoid follicle formation (p=0.007), pleural invasion (p=0.025), vascular invasion (p=0.013), and appearance of CD3/25/FoxP3-triple positive regulatory T cell (p=0.097) were correlated with overall survival. Multivariate analysis revealed that lymphoid follicle formation (p=0.042) and pleural invasion (p=0.040) were independent prognostic factors related to overall survival, whereas CD3/25/FoxP3-triple positive regulatory T cells were not.

      Conclusion

      Appearance of CD3/25/FoxP3-triple positive regulatory T cell was correlated with lymphoid follicle formation. Lymphoid follicle formation, rather than appearance of CD3/25/FoxP3-triple positive regulatory T cell, is a predictor of patient survival following surgery for lung SCC.

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