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Yoshihisa Umekita



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    EP1.04 - Immuno-oncology (ID 194)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Immuno-oncology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.04-01 - Association of PD-L1 Expression with Lung Adenocarcinoma Containing Solid or Micropapillary Components (Now Available) (ID 1549)

      08:00 - 18:00  |  Author(s): Yoshihisa Umekita

      • Abstract
      • Slides

      Background

      The assessment of programmed cell death ligand 1 (PD-L1) expression by immunohistochemistry (IHC) is important to treat patients in lung adenocarcinoma (LUAD). However, little is known about the relationship between PD-L1 expression and high-grade components, such as solid components (SCs) and/or micropapillary components (MPCs), which show worse prognosis. Here, the aim of this study is to evaluate the association of the PD-L1 expression with LUAD containing high-grade components.

      Method

      The expression of PD-L1 protein in 39 surgically resected LUAD was evaluated by IHC analysis using the clone 22C3. PD-L1 tumor proportion score (TPS) were divided to three groups: TPS at least ≥50% was high expression, ≥1% was intermediate expression, and <1% was negative expression. We compared retrospectively the three groups and the percentage of high-grade components.

      Result

      PD-L1 high expression was seen in eight patients (20.5%), intermediate expression in 22 patients (56.4%), and negative expression in 9 patients (23.1%). Thirty five cases with at least ≥1% SCs and/or MPCs were identified. The mean of the percentage of high-grade components was 60% in high expression group, 22% in intermediate expression group, and 10% in negative expression group. The statistical significance was shown comparing the PD-L1 high expression with the intermediate expression group (p<0.013), and comparing the high expression and the negative expression group (p<0.002).

      Conclusion

      LUAD with many high-grade components showed the PD-L1 high expression. Therefore, PD-L1 IHC should be performed on sections including a high percentage of SCs and/or MPCs in evaluating its expression in surgical resected specimen.

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