Start Your Search
EP1.04 - Immuno-oncology (ID 194)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Immuno-oncology
- Presentations: 1
- Now Available
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
EP1.04-01 - Association of PD-L1 Expression with Lung Adenocarcinoma Containing Solid or Micropapillary Components (Now Available) (ID 1549)
08:00 - 18:00 | Author(s): Yuji Taniguchi
The assessment of programmed cell death ligand 1 (PD-L1) expression by immunohistochemistry (IHC) is important to treat patients in lung adenocarcinoma (LUAD). However, little is known about the relationship between PD-L1 expression and high-grade components, such as solid components (SCs) and/or micropapillary components (MPCs), which show worse prognosis. Here, the aim of this study is to evaluate the association of the PD-L1 expression with LUAD containing high-grade components.Method
The expression of PD-L1 protein in 39 surgically resected LUAD was evaluated by IHC analysis using the clone 22C3. PD-L1 tumor proportion score (TPS) were divided to three groups: TPS at least ≥50% was high expression, ≥1% was intermediate expression, and <1% was negative expression. We compared retrospectively the three groups and the percentage of high-grade components.Result
PD-L1 high expression was seen in eight patients (20.5%), intermediate expression in 22 patients (56.4%), and negative expression in 9 patients (23.1%). Thirty five cases with at least ≥1% SCs and/or MPCs were identified. The mean of the percentage of high-grade components was 60% in high expression group, 22% in intermediate expression group, and 10% in negative expression group. The statistical significance was shown comparing the PD-L1 high expression with the intermediate expression group (p<0.013), and comparing the high expression and the negative expression group (p<0.002).Conclusion
LUAD with many high-grade components showed the PD-L1 high expression. Therefore, PD-L1 IHC should be performed on sections including a high percentage of SCs and/or MPCs in evaluating its expression in surgical resected specimen.
Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.