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Klaus Kaier



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    P2.17 - Treatment of Early Stage/Localized Disease (ID 189)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Treatment of Early Stage/Localized Disease
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.17-19 - Quality of Life After Pulmonary Stereotactic Fractionated Radiotherapy: Longterm Results of the Phase II STRIPE Trial (ID 2142)

      10:15 - 18:15  |  Author(s): Klaus Kaier

      • Abstract

      Background

      Preserving health related quality of life (HRQOL) plays an important role in considering stereotactic body fractionated radiotherapy (SBRT). The prospective monocenter phase II STRIPE trial investigated long-term HRQOL after SBRT, efficacy and toxicity.

      Method

      Patients with ≤ 2 pulmonary lesions ≤ 5cm were treated with 4DPET/CT-based SBRT (3X12.5Gy or risk-adapted 5X7Gy, to the 60% isodose). Follow up (FU) was performed 2 and 7 weeks after SBRT, then 3monthly for 2 years with assessment of response (primary endpoint: 2-year cumulative incidence of local progression (LP); secondary endpoints: local progression free (LPFS), overall survival (OS) and toxicity (CTCAE)). Impact of predefined patient and treatment related factors on HRQOL (EORTC QLQ-C30 and EORTC QLQ-LC13) was evaluated.

      Result

      Between 02/2011 and11/2014, 100 patients were given SBRT for 56 NSCLC and 44 pulmonary metastases. Long-term FU overall revealed stable Quality of Life (QoL)/Global health status (GHS), functions-scores and symptoms. For QoL/GHS, patients with low initial QoL/GHS-Score below the median of 50, revealed significantly stronger improvement than those with good QoL/GHS-scores (p< 0.001). Probability for LP, LPFS and OS 2 years after SBRT was 8.1%, 53.3% and 62.2%. Lower risk for LP was revealed for 3X12.5Gy (p=0.043) and for Dmin (Biological Effective Dose10) in the Planning Target Volume>100Gy (p=0.023). ≥G3-Toxicity was < 4%, except dyspnea: ≥G3 dyspnea was 6% at baseline and 14.5% 2 years after SBRT.

      Conclusion

      These prospective data on a representative cohort of pulmonary SBRT patients confirm a stable preservation of HRQOL after SBRT and furthermore demonstrate a QoL/GHS-benefit for patients with low initial QoL/GHS-scores, the regimen of 3x12.5 Gy SBRT being efficient and well tolerated. This result may inform shared decision making when discussing SBRT for frail patients