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  P2.17 - Treatment of Early Stage/Localized Disease (ID 189)

  • Event: WCLC 2019
  • Type: Poster Viewing in the Exhibit Hall
  • Track: Treatment of Early Stage/Localized Disease
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall

  • 31798

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    P2.17-15 - Clinical Features and Prognosis of Lung Cancer with Cavity Lesion (ID 2023)

    10:15 - 18:15  |  Presenting Author(s): Hiromichi Okuma
    • Abstract
    • Slides

    Background
    

    There have been conflicting results about the clinical features and prognosis of primary lung cancer with cavity lesion (LC-CL). We, therefore, revisited the clinicopathological features of primary LC-CL and reassessed whether they exhibited poor prognosis in non-small-cell lung cancer.

    Method
    

    Between 2006 and 2014, 377 patients underwent complete resection for clinical T1aN0 non-small-cell lung cancer. Clinical stage was adapted to the seventh edition of the lung cancer stage classification system. Among these cases, 23 (6.1%) were diagnosed as LC-CL. We compared the characteristics and prognosis between LC-CL and the others.

    Result
    

    LC-CL showed higher CEA (≧5 ng/mL) (p<0.01), higher SUV max (≧2.5) (p=0.02), the status of smoking history (p<0.01), larger actual pathologic tumor size (≧3cm) (p<0.01), lymphatic invasion (p=0.03), as compared with the others. The overall and recurrence-free survival of the patients with LC-CL were shorter than those of the others (p=0.01 and 0.03, respectively). Univariate analysis revealed that sex (p=0.01), age (≧70) (p<0.01), CEA (p<0.01), SUV max (p<0.01), smoking history (p<0.01), pathologic tumor stage (≧Ⅱ) (p=0.01), vascular invasion (p<0.01), lymphatic invasion (p=0.04), pleural invasion (p<0.01) and cavity lesion (p=0.01) showed significant poor prognostic factors. Multivariate analysis revealed that age (p=0.02) and SUV max (p<0.01) remained significant prognostic factors, but cavity lesion was not significant (p=0.17).

    Conclusion
    

    Although the value of its prognostic factor was not significant, primary LC-CL should be considered to have aggressive malignant behavior in non-small-cell lung cancer.

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