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Blanca De La Puente Orteu



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    P2.16 - Treatment in the Real World - Support, Survivorship, Systems Research (ID 187)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Treatment in the Real World - Support, Survivorship, Systems Research
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.16-34 - Is Prophylactic Cranial Irradiation Useful in Real World? (Now Available) (ID 1398)

      10:15 - 18:15  |  Author(s): Blanca De La Puente Orteu

      • Abstract
      • Slides

      Background

      Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype. Just one third of patients are diagnosed as limited stage (LS), in which the goal is to perform a radical treatment. However, the majority will develop metastasis, being in central nervous system (CNS) one of the most frequent. In patients with LS, after systemic treatment, prophylactic cranial irradiation (PCI) should be considered. Nevertheless, the effectiveness of PCI has been a controversial issue in terms of overall survival (OS).

      Method

      A cohort of 81 patients diagnosed of localized SCLC were retrospectively analyzed in our center over a 10-year period (January 2008-December 2017). Brain imagen was done before chemo-radiotherapy (CRT) and repeated before PCI. Baseline demographics characteristics and brain metastases rate incidence were described.

      Result

      From 81 patients, 48 received PCI and 33 did not. Complete baseline characteristics from both groups are shown in table 1. No differences were found in performance status at diagnosis between groups . From those who did not receive PCI, 8 (26%) had developed brain metastases after CRT and before PCI. Brain metastases incidence rate in PCI subgroup was 9/100 people per year vs 35/100 people per year in those who did not receive PCI, in whom 54.5% had brain or systemic progression before PCI planning. Progression free survival in both subgroups was 13.5 months and OS was 21.2 months.

      imagen 1.png

      Conclusion

      In our series, PCI had a significant effect in decreasing brain metastases. This study also confirms the requirement of brain imaging to confirm lack of brain metastases after initial CRT and before PCI.

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